PXD043815

PXD043815 is an original dataset announced via ProteomeXchange.

Title	Pathogenesis of chikungunya virus infection associated with fatal outcome
Description	Chikungunya virus (CHIKV) is a mosquito-borne virus that causes acute, subacute, and chronic human diseases and can cause neurological complications and death. Here, we combined epidemiological, virological, histopathological, cytokine, molecular dynamics, metabolomics, proteomics, and genomic analyses to investigate viral and pathophysiologic factors that contribute to deaths caused by chikungunya (CHIK). Our results indicate that CHIK-deaths presented multiple organs infection, central nervous system damage, and exhibited significantly elevated serum levels of pro-inflammatory cytokines and chemokines compared to survivors. The histopathology, metabolite, and proteomic signatures of CHIK-deaths revealed hemodynamic disorders and dysregulated immune system response. CHIKV East-Central-South-African lineage caused fatal and survivor cases, and CHIKV crosses the blood–brain barrier without tight junction alterations. IFN-λ3 was highly expressed in fatal cases but did not present a direct antiviral effect on CHIKV replication in vitro. In summary, our results reveal insights to improve understanding of CHIK pathogenesis, especially the pathophysiology of fatal infections.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:46:02.185.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD043815
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Victor Corasolla Carregari
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2023-07-16 04:08:45	ID requested
1	2024-06-16 07:58:21	announced
⏵ 2	2024-10-22 06:46:03	announced	2024-10-22: Updated project metadata.

de Souza WM, Fumagalli MJ, de Lima STS, Parise PL, Carvalho DCM, Hernandez C, de Jesus R, Delafiori J, Candido DS, Carregari VC, Muraro SP, Souza GF, Sim, õ, es Mello LM, Claro IM, D, í, az Y, Kato RB, Trentin LN, Costa CHS, Maximo ACBM, Cavalcante KF, Fiuza TS, Viana VAF, Melo MEL, Ferraz CPM, Silva DB, Duarte LMF, Barbosa PP, Amorim MR, Judice CC, Toledo-Teixeira DA, Ramundo MS, Aguilar PV, Ara, ú, jo ELL, Costa FTM, Cerqueira-Silva T, Khouri R, Boaventura VS, Figueiredo LTM, Fang R, Moreno B, L, ó, pez-Verg, è, s S, Mello LP, Skaf MS, Catharino RR, Granja F, Martins-de-Souza D, Plante JA, Plante KS, Sabino EC, Diamond MS, Eugenin E, Proen, ç, a-M, ó, dena JL, Faria NR, Weaver SC, Pathophysiology of chikungunya virus infection associated with fatal outcomes. Cell Host Microbe, 32(4):606-622.e8(2024) [pubmed]

10.6019/PXD043815;

10.1016/j.chom.2024.02.011;

submitter keyword: Chikungunya infection,Plasma Proteomics, Immune Response

Daniel Martins-de-Souza
contact affiliation	Professor of Biochemistry Chair of the Dept. of Biochemistry and Tissue Biology Head of the Laboratory of Neuroproteomics University of Campinas (UNICAMP), Brazil.
contact email	danms90@gmail.com
lab head
Victor Corasolla Carregari
contact affiliation	Post doctor
contact email	corasolla@gmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD043815
     1. Label: PRIDE project
     2. Name: Pathogenesis of chikungunya virus infection associated with fatal outcome