⮝ Full datasets listing
PXD043776
PXD043776 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | BCAT1 Confers Resistance to EGFR TKIs through α-KG-dependent Epigenetic Regulation of the Glycolysis Pathway in NSCLC |
| Description | Epidermal growth factor receptor (EGFR) mutations are leading oncogenic drivers in non-small cell lung cancer (NSCLC). Many third-generation EGFR tyrosine kinase inhibitors (TKIs) have been developed to target EGFR T790M and activating mutations. Osimertinib (AZD9291) was the first approved drug and is now the standard-of-care therapy for untreated EGFR-mutated NSCLC. Our team previously identified ASK120067, for which we have submitted a new drug application (NDA) in China. Although third-generation EGFR TKIs exhibit favorable antitumor effects in NSCLC treatment, acquired resistance with largely unexplored mechanisms still limits their long-term efficacy. In this study, we aimed to investigate the molecular mechanisms underlying resistance to EGFR TKIs and identify new therapeutic strategies for the treatment of NSCLC. Methods: Elevated expression of BCAT1 in EGFR TKI-resistant lung cancer cells was identified using stable isotope labeling by amino acids in cell culture (SILAC)-based proteomics analysis and verified with Western blotting and RT‒qPCR. |
| HostingRepository | iProX |
| AnnounceDate | 2023-07-14 |
| AnnouncementXML | Submission_2024-08-15_19:30:51.951.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jing Gao |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-07-13 19:49:36 | ID requested | |
| ⏵ 1 | 2024-08-15 19:30:52 | announced |
Publication List
Keyword List
| submitter keyword: EGFR TKI, Drug resistance, BCAT1, α-KG, Glycolysis |
Contact List
| Hu Zhou | |
|---|---|
| contact affiliation | Shanghai Institute of Materia Medica, Chinese Academy of Sciences |
| contact email | zhouhu@simm.ac.cn |
| lab head | |
| Jing Gao | |
| contact affiliation | Shanghai Institute of Materia Medica, Chinese Academy of Sciences |
| contact email | jinggao@simm.ac.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
