PXD043775
PXD043775 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteogenomics of urothelial bladder cancer progression reveals the distinguished molecular features of different pathological subtypes |
| Description | We reported a comprehensive proteogenomics analysis, including whole-genome sequencing, RNA sequencing, and proteomics and phosphoproteomics profiling, of 448 trace-tumor-samples from 190 urothelial bladder neoplasm patients, covering the whole spectrum of disease stages and grades. DNA damage was a key signaling pathway in the progression of carcinoma in situ (CIS) and related to APOBEC signature. Proteogenomic integration analysis indicated the mutation of HRAS regulated mTOR signaling to form urothelial papilloma rather than papillary urothelial cancer (PUC). Glucolipid metabolism increase and lower immune cell infiltration were significantly associated with PUC compared to CIS. Proteomic analysis distinguished the origins of invasive tumors (PUC-derived and CIS-derived), related to distinct clinical prognosis and molecular features. Additionally, loss of RBPMS, associated with CIS-derived tumors, was validated to increase the activity of SMAD-bound JUN and promote metastasis. |
| HostingRepository | iProX |
| AnnounceDate | 2023-08-02 |
| AnnouncementXML | Submission_2023-09-18_21:07:58.316.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Ning Xu |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | monohydroxylated residue |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-07-13 19:23:23 | ID requested | |
| 1 | 2023-07-13 21:10:57 | announced | |
| 2 | 2023-08-04 20:23:05 | announced | 2023-08-05: Update information. |
| ⏵ 3 | 2023-09-18 21:07:59 | announced | 2023-08-05: Update information. 2023-09-19: Update publication information. |
Publication List
| Yao Z, Xu N, Shang G, Wang H, Tao H, Wang Y, Qin Z, Tan S, Feng J, Zhu J, Ma F, Tian S, Zhang Q, Qu Y, Hou J, Guo J, Zhao J, Hou Y, Ding C, Proteogenomics of different urothelial bladder cancer stages reveals distinct molecular features for papillary cancer and carcinoma in situ. Nat Commun, 14(1):5670(2023) [pubmed] |
Keyword List
| submitter keyword: early urothelial bladder cancer, uc progression, proteogenomics |
Contact List
| Chen Ding | |
|---|---|
| contact affiliation | Fudan University |
| contact email | chend@fudan.edu.cn |
| lab head | |
| Ning Xu | |
| contact affiliation | Fudan University |
| contact email | nxu19@fudan.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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