PXD043774
PXD043774 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Plasma proteomic profiling discovers molecular features associated with upper urinary tract urothelial carcinoma |
| Description | Upper tract urothelial carcinoma (UTUC) is often diagnosed late and exhibits poor prognosis. Only limited data are available concerning potential noninvasive biomarkers for disease monitoring. Here, we investigated the proteomic profile of plasma in 362 UTUC patients and 239 healthy control samples. The results show 520 elevated proteins in UTUC patients are mainly involved in acute-phase response and tRNA aminoacylation pathways; while 317 descend proteins are enriched in sulfur metabolism and deubiquitination. We presented an integrated tissue-plasma proteomic approach to infer the highly specific tumor biomarkers for identify patients with muscle-invasive UTUC. We provided a protein panel that reflected lymph node metastasis, which is of interest to identify high risk and poor prognosis UTUC patients. We also identified a ten-gene signature and establishment of a prognostic nomogram predicting progression-free survival of UTUC. Finally, we further validated the biomarkers by parallel reaction monitoring (PRM) assay in a new independent cohort. |
| HostingRepository | iProX |
| AnnounceDate | 2023-07-12 |
| AnnouncementXML | Submission_2023-10-26_19:10:17.611.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Ning Xu |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | monohydroxylated residue |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-07-13 19:13:40 | ID requested | |
| 1 | 2023-07-13 21:12:43 | announced | |
| ⏵ 2 | 2023-10-26 19:10:18 | announced | 2023-10-27: Update publication information. |
Publication List
| Qu Y, Yao Z, Xu N, Shi G, Su J, Ye S, Chang K, Li K, Wang Y, Tan S, Pei X, Chen Y, Qin Z, Feng J, Lv J, Zhu J, Ma F, Tang S, Xu W, Tian X, Anwaier A, Tian S, Xu W, Wu X, Zhu S, Zhu Y, Cao D, Sun M, Gan H, Zhao J, Zhang H, Ye D, Ding C, Plasma proteomic profiling discovers molecular features associated with upper tract urothelial carcinoma. Cell Rep Med, 4(9):101166(2023) [pubmed] |
Keyword List
| submitter keyword: plasma proteomic, upper tract urothelial carcinoma |
Contact List
| Chen Ding | |
|---|---|
| contact affiliation | Fudan University |
| contact email | chend@fudan.edu.cn |
| lab head | |
| Ning Xu | |
| contact affiliation | Fudan University |
| contact email | nxu19@fudan.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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