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PXD043773

PXD043773 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitlePeptide toxins that target vertebrate voltage-gated sodium channels underly the painful stings of harvester ants
DescriptionHarvester ants (genus Pogonomyrmex) are notable for their stings which cause intense, long-lasting pain and other neurotoxic symptoms in vertebrates. Here we show that harvester ant venoms are relatively simple and composed largely of peptide toxins. One class of peptides is primarily responsible for the long-lasting local pain of envenomation. These hydrophobic, cysteine-free peptides activate mammalian sensory neurons via potent modulation of voltage-gated sodium (NaV) channels, reducing voltage threshold for activation and inhibiting channel inactivation. These toxins appear to have evolved specifically as deterrents against vertebrates.
HostingRepositoryPRIDE
AnnounceDate2024-06-16
AnnouncementXMLSubmission_2024-06-16_01:09:28.387.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterVanessa Schendel
SpeciesList scientific name: Pogonomyrmex; NCBI TaxID: 144030;
ModificationListNo PTMs are included in the dataset
InstrumentTripleTOF 5600
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-07-13 18:04:55ID requested
12024-06-16 01:09:29announced
Publication List
Robinson SD, Deuis JR, Niu P, Touchard A, Mueller A, Schendel V, Brinkwirth N, King GF, Vetter I, Schmidt JO, Peptide toxins that target vertebrate voltage-gated sodium channels underly the painful stings of harvester ants. J Biol Chem, 300(1):105577(2024) [pubmed]
10.1016/j.jbc.2023.105577;
Keyword List
submitter keyword: pain, hymenoptera,venoms, defence, ants
Contact List
Samuel D. Robinson
contact affiliationInstitute for Molecular Bioscience, University of Queensland; QLD 4072, Australia
contact emailsam.robinson@uq.edu.au
lab head
Vanessa Schendel
contact affiliationUniversity of Queensland
contact emailv.schendel@uq.edu.au
dataset submitter
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Dataset FTP location
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