PXD043773 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Peptide toxins that target vertebrate voltage-gated sodium channels underly the painful stings of harvester ants |
Description | Harvester ants (genus Pogonomyrmex) are notable for their stings which cause intense, long-lasting pain and other neurotoxic symptoms in vertebrates. Here we show that harvester ant venoms are relatively simple and composed largely of peptide toxins. One class of peptides is primarily responsible for the long-lasting local pain of envenomation. These hydrophobic, cysteine-free peptides activate mammalian sensory neurons via potent modulation of voltage-gated sodium (NaV) channels, reducing voltage threshold for activation and inhibiting channel inactivation. These toxins appear to have evolved specifically as deterrents against vertebrates. |
HostingRepository | PRIDE |
AnnounceDate | 2024-06-16 |
AnnouncementXML | Submission_2024-06-16_01:09:28.387.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Vanessa Schendel |
SpeciesList | scientific name: Pogonomyrmex; NCBI TaxID: 144030; |
ModificationList | No PTMs are included in the dataset |
Instrument | TripleTOF 5600 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-07-13 18:04:55 | ID requested | |
⏵ 1 | 2024-06-16 01:09:29 | announced | |
Publication List
Robinson SD, Deuis JR, Niu P, Touchard A, Mueller A, Schendel V, Brinkwirth N, King GF, Vetter I, Schmidt JO, Peptide toxins that target vertebrate voltage-gated sodium channels underly the painful stings of harvester ants. J Biol Chem, 300(1):105577(2024) [pubmed] |
10.1016/j.jbc.2023.105577; |
Keyword List
submitter keyword: pain, hymenoptera,venoms, defence, ants |
Contact List
Samuel D. Robinson |
contact affiliation | Institute for Molecular Bioscience, University of Queensland; QLD 4072, Australia |
contact email | sam.robinson@uq.edu.au |
lab head | |
Vanessa Schendel |
contact affiliation | University of Queensland |
contact email | v.schendel@uq.edu.au |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/06/PXD043773 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD043773
- Label: PRIDE project
- Name: Peptide toxins that target vertebrate voltage-gated sodium channels underly the painful stings of harvester ants