PXD043773

PXD043773 is an original dataset announced via ProteomeXchange.

Title	Peptide toxins that target vertebrate voltage-gated sodium channels underly the painful stings of harvester ants
Description	Harvester ants (genus Pogonomyrmex) are notable for their stings which cause intense, long-lasting pain and other neurotoxic symptoms in vertebrates. Here we show that harvester ant venoms are relatively simple and composed largely of peptide toxins. One class of peptides is primarily responsible for the long-lasting local pain of envenomation. These hydrophobic, cysteine-free peptides activate mammalian sensory neurons via potent modulation of voltage-gated sodium (NaV) channels, reducing voltage threshold for activation and inhibiting channel inactivation. These toxins appear to have evolved specifically as deterrents against vertebrates.
HostingRepository	PRIDE
AnnounceDate	2024-06-16
AnnouncementXML	Submission_2024-06-16_01:09:28.387.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Vanessa Schendel
SpeciesList	scientific name: Pogonomyrmex; NCBI TaxID: 144030;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2023-07-13 18:04:55	ID requested
⏵ 1	2024-06-16 01:09:29	announced

Robinson SD, Deuis JR, Niu P, Touchard A, Mueller A, Schendel V, Brinkwirth N, King GF, Vetter I, Schmidt JO, Peptide toxins that target vertebrate voltage-gated sodium channels underly the painful stings of harvester ants. J Biol Chem, 300(1):105577(2024) [pubmed]

10.1016/j.jbc.2023.105577;

submitter keyword: pain, hymenoptera,venoms, defence, ants

Samuel D. Robinson
contact affiliation	Institute for Molecular Bioscience, University of Queensland; QLD 4072, Australia
contact email	sam.robinson@uq.edu.au
lab head
Vanessa Schendel
contact affiliation	University of Queensland
contact email	v.schendel@uq.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/06/PXD043773

PRIDE project URI

• PRIDE
  1. PXD043773
     1. Label: PRIDE project
     2. Name: Peptide toxins that target vertebrate voltage-gated sodium channels underly the painful stings of harvester ants