PXD043768

PXD043768 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomic analysis of right-ventricular dysfunction (RVD) in patients with advanced chronic heart failure.
Description	This research aimed to identify protein biomarkers of right ventricular dysfunction in patients with advanced heart failure with reduced ejection fraction (HFrEF). Samples of myocardium from both, right and left ventricles (RV, LV) were obtained from 10 HFrEF patients with right ventricular dysfunction (RVD), 10 HFrEF patients without RVD (noRVD) undergoing heart transplantation, and 10 non-failing unused donor hearts (Control). Tissue samples were homogenized and extracted using mild Triton X-100 detergent and processed by SP3 extraction to remove the detergent prior the analysis, (LFQ) proteomic analysis identified a total of 4 032 proteins in the left ventricle and 3 788 proteins in the right ventricle.
HostingRepository	PRIDE
AnnounceDate	2025-02-11
AnnouncementXML	Submission_2025-02-11_07:39:51.475.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Matěj Běhounek
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-07-13 10:14:57	ID requested
⏵ 1	2025-02-11 07:39:52	announced

Publication List

B, ě, hounek M, Lipcseyov, á D, V, í, t O, Ž, á, č, ek P, Talacko P, Huskov, á Z, Kikerlov, á S, Tykvartov, á T, Wohlfahrt P, Melenovsk, ý V, Bene, š J, Petr, á, k J, Biomarkers of RV Dysfunction in HFrEF Identified by Direct Tissue Proteomics: Extracellular Proteins Fibromodulin and Fibulin-5. Circ Heart Fail, 18(3):e011984(2025) [pubmed]
10.1161/circheartfailure.124.011984;

B, ě, hounek M, Lipcseyov, á D, V, í, t O, Ž, á, č, ek P, Talacko P, Huskov, á Z, Kikerlov, á S, Tykvartov, á T, Wohlfahrt P, Melenovsk, ý V, Bene, š J, Petr, á, k J, Biomarkers of RV Dysfunction in HFrEF Identified by Direct Tissue Proteomics: Extracellular Proteins Fibromodulin and Fibulin-5. Circ Heart Fail, 18(3):e011984(2025) [pubmed]

10.1161/circheartfailure.124.011984;

Keyword List

submitter keyword: myocardium, Right ventricular dysfunction, LFQ, Triton X-100,Chronic heart failure, Biomarkers, RVD

submitter keyword: myocardium, Right ventricular dysfunction, LFQ, Triton X-100,Chronic heart failure, Biomarkers, RVD

Contact List

Doc. RNDr. Jiří Petrák, Ph.D.
contact affiliation	BIOCEV, First Faculty of Medicine, Charles University, Prague, Czech Republic
contact email	jpetr@lf1.cuni.cz
lab head
Matěj Běhounek
contact affiliation	BIOCEV, First Faculty of Medicine, Charles University, Prague, Czech Republic
contact email	matej.behounek@lf1.cuni.cz
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/02/PXD043768
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/02/PXD043768

PRIDE project URI

Repository Record List

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