PXD043763

PXD043763 is an original dataset announced via ProteomeXchange.

Title	Determination of the mechanisms of hepatotoxicity induced by chlordecone and chlordecol from primary human hepatocytes cells and proteomic analyzes
Description	Chlordecone (CLD) is a pesticide used to control the banana weevill in the French West Indies from 1970 to 1993. Despite its ban in the 90s, the highly persistence of CLD and contamination of the food webs raised tremendous concern for public health [1]. CLD can induce reprotoxic, neurotoxic and hepatotoxic effects in humans and is involved in prostate cancer [2] and liver fibrosis potentiation [3]. In liver, although CLD is metabolized into phase I metabolite chlordecol (CLD-OH), it is highly biopersistent. Nevertheless, the cellular hepatic effects of these 2 compounds have been poorly described. Therefore, we used an original approach to investigate in vitro toxicity responses of CLD and CLD-OH in liver cell models (HepaRG cells and primary human hepatocytes, PHHs) using metabolomics and proteomics. 1) Resiere, D., et al. (2023). Chlordecone (Kepone) poisoning in the French Territories in the Americas. Lancet 401, 916. 2) Multigner L., et al. (2010). Chlordecone exposure and risk of prostate cancer. J Clin Oncol 28, 3457-3462. 3) Tabet E., et al. (2016). Chlordecone potentiates hepatic fibrosis in chronic liver injury induced by carbon tetrachloride in mice. Toxicol Lett 255, 1-10.
HostingRepository	PRIDE
AnnounceDate	2025-06-10
AnnouncementXML	Submission_2025-06-10_05:03:34.233.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD043763
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Thibaut LEGER
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2023-07-13 07:52:52	ID requested
⏵ 1	2025-06-10 05:03:35	announced

10.6019/PXD043763;

10.1016/j.jhazmat.2022.130083;

L, é, ger T, Balaguer P, Le H, é, garat L, Fessard V, and STATs-driven effects of the mitochondrial complex I inhibitor tebufenpyrad in liver cells revealed with multi-omics. J Hazard Mater, 442():130083(2023) [pubmed]

submitter keyword: chlordecol, pesticide, metabolism, kepone, proteomics, multi-omics, metabolomics, septins, mitochondrion, liver, toxicology,chlordecone

Thibaut LEGER
contact affiliation	ANSES FOUGERES FRANCE
contact email	thibaut.leger@anses.fr
lab head
Thibaut LEGER
contact affiliation	French Agency for Food, Environmental and Occupational Health & Safety (ANSES)
contact email	thibaut.leger@anses.fr
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD043763
     1. Label: PRIDE project
     2. Name: Determination of the mechanisms of hepatotoxicity induced by chlordecone and chlordecol from primary human hepatocytes cells and proteomic analyzes