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PXD043728

PXD043728 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleHydration status of geriatric patients is associated with changes of serum proteome especially of proteins involved in coagulation
DescriptionDue to multifactorial reasons, such as decreased thirst and decreased total body water, elderly patients are vulnerable to dehydration. The study aims to investigate whether moderate dehydration or hyperhydration affects the blood proteome. Blood samples, medication and bioelectrical impedance analysis (BIA) details were collected from 131 geriatric patients (77 women, 54 men). Based on an evaluation by Bioelectrical Impedance Vector Analyses (BIVA) of this cohort, for each hydration status (dehydrated, hyperhydrated and control), five appropriate blood serum samples for both male and female were analyzed by LC-MS. Overall, 262 proteins for female patients and 293 proteins for male patients could be quantified. 38 proteins had significantly different abundance, showing that hydration status does indeed affect the serum proteome. Protein enrichment analysis of the affected proteins revealed “Wound Healing” and “Keratinization” as the two main biological processes being dysregulated. Especially, proteins involved in clot formation are affected by hydration status.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_06:12:55.257.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJohannes Schmidt
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListacetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-07-12 13:23:05ID requested
12023-10-24 13:42:22announced
22023-11-14 09:12:44announced2023-11-14: Updated project metadata.
32024-10-22 06:12:56announced2024-10-22: Updated project metadata.
Publication List
10.3390/nu15173789;
Keyword List
submitter keyword: dehydration, alzheimer, wound healing, hyperhydration, serum, coagulation, dementia, tmt,human, biomarker, tandem mass tags
Contact List
Johannes Schmidt
contact affiliationCoburg University of Applied Sciences and Arts, Institute for Bioanalysis, Friedrich-Streib-Str. 2, D-96450 Coburg, Germany
contact emailstefan.kalkhof@hs-coburg.de
lab head
Johannes Schmidt
contact affiliationFraunhofer Institute for Cell Therapy and Immunology
contact emailjohannes.schmidt@izi.fraunhofer.de
dataset submitter
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Dataset FTP location
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