PXD043728

PXD043728 is an original dataset announced via ProteomeXchange.

Title	Hydration status of geriatric patients is associated with changes of serum proteome especially of proteins involved in coagulation
Description	Due to multifactorial reasons, such as decreased thirst and decreased total body water, elderly patients are vulnerable to dehydration. The study aims to investigate whether moderate dehydration or hyperhydration affects the blood proteome. Blood samples, medication and bioelectrical impedance analysis (BIA) details were collected from 131 geriatric patients (77 women, 54 men). Based on an evaluation by Bioelectrical Impedance Vector Analyses (BIVA) of this cohort, for each hydration status (dehydrated, hyperhydrated and control), five appropriate blood serum samples for both male and female were analyzed by LC-MS. Overall, 262 proteins for female patients and 293 proteins for male patients could be quantified. 38 proteins had significantly different abundance, showing that hydration status does indeed affect the serum proteome. Protein enrichment analysis of the affected proteins revealed “Wound Healing” and “Keratinization” as the two main biological processes being dysregulated. Especially, proteins involved in clot formation are affected by hydration status.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:12:55.257.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Johannes Schmidt
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-07-12 13:23:05	ID requested
1	2023-10-24 13:42:22	announced
2	2023-11-14 09:12:44	announced	2023-11-14: Updated project metadata.
⏵ 3	2024-10-22 06:12:56	announced	2024-10-22: Updated project metadata.

10.3390/nu15173789;

Hoen L, Pfeffer D, Schmidt JR, Kraft J, Hildebrand J, Kalkhof S, Hydration Status of Geriatric Patients Is Associated with Changes in Plasma Proteome, Especially in Proteins Involved in Coagulation. Nutrients, 15(17):(2023) [pubmed]

submitter keyword: dehydration, alzheimer, wound healing, hyperhydration, serum, coagulation, dementia, tmt,human, biomarker, tandem mass tags

Johannes Schmidt
contact affiliation	Coburg University of Applied Sciences and Arts, Institute for Bioanalysis, Friedrich-Streib-Str. 2, D-96450 Coburg, Germany
contact email	stefan.kalkhof@hs-coburg.de
lab head
Johannes Schmidt
contact affiliation	Fraunhofer Institute for Cell Therapy and Immunology
contact email	johannes.schmidt@izi.fraunhofer.de
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD043728
     1. Label: PRIDE project
     2. Name: Hydration status of geriatric patients is associated with changes of serum proteome especially of proteins involved in coagulation