PXD043728 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Hydration status of geriatric patients is associated with changes of serum proteome especially of proteins involved in coagulation |
Description | Due to multifactorial reasons, such as decreased thirst and decreased total body water, elderly patients are vulnerable to dehydration. The study aims to investigate whether moderate dehydration or hyperhydration affects the blood proteome. Blood samples, medication and bioelectrical impedance analysis (BIA) details were collected from 131 geriatric patients (77 women, 54 men). Based on an evaluation by Bioelectrical Impedance Vector Analyses (BIVA) of this cohort, for each hydration status (dehydrated, hyperhydrated and control), five appropriate blood serum samples for both male and female were analyzed by LC-MS. Overall, 262 proteins for female patients and 293 proteins for male patients could be quantified. 38 proteins had significantly different abundance, showing that hydration status does indeed affect the serum proteome. Protein enrichment analysis of the affected proteins revealed “Wound Healing” and “Keratinization” as the two main biological processes being dysregulated. Especially, proteins involved in clot formation are affected by hydration status. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:12:55.257.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Johannes Schmidt |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-07-12 13:23:05 | ID requested | |
1 | 2023-10-24 13:42:22 | announced | |
2 | 2023-11-14 09:12:44 | announced | 2023-11-14: Updated project metadata. |
⏵ 3 | 2024-10-22 06:12:56 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.3390/nu15173789; |
Hoen L, Pfeffer D, Schmidt JR, Kraft J, Hildebrand J, Kalkhof S, Hydration Status of Geriatric Patients Is Associated with Changes in Plasma Proteome, Especially in Proteins Involved in Coagulation. Nutrients, 15(17):(2023) [pubmed] |
Keyword List
submitter keyword: dehydration, alzheimer, wound healing, hyperhydration, serum, coagulation, dementia, tmt,human, biomarker, tandem mass tags |
Contact List
Johannes Schmidt |
contact affiliation | Coburg University of Applied Sciences and Arts, Institute for Bioanalysis, Friedrich-Streib-Str. 2, D-96450 Coburg, Germany |
contact email | stefan.kalkhof@hs-coburg.de |
lab head | |
Johannes Schmidt |
contact affiliation | Fraunhofer Institute for Cell Therapy and Immunology |
contact email | johannes.schmidt@izi.fraunhofer.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD043728
- Label: PRIDE project
- Name: Hydration status of geriatric patients is associated with changes of serum proteome especially of proteins involved in coagulation