PXD043629
PXD043629 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Discovery of Cisplatin-binding Proteins by Competitive Cysteinome Profiling |
| Description | Cisplatin is a widely-used cancer metallodrug which induces cytotoxicity by targeting DNA and chelating cysteines in proteins. Here we applied a competitive activity-based protein profiling strategy to identify cisplatin-binding cysteines in cancer proteomes. A novel cisplatin target, MetAP1, was found and functionally validated to contribute to cisplatin’s cytotoxicity. |
| HostingRepository | iProX |
| AnnounceDate | 2023-07-08 |
| AnnouncementXML | Submission_2024-05-27_21:29:30.259.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Xianghe Wang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | trimethylated residue |
| Instrument | Q Exactive; Q Exactive Plus |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-07-09 23:51:50 | ID requested | |
| 1 | 2023-07-09 23:51:57 | announced | |
| ⏵ 2 | 2024-05-27 21:29:31 | announced | 2024-05-28: Update information. |
Publication List
| Wang X, Zhang Y, Wang C, Discovery of cisplatin-binding proteins by competitive cysteinome profiling. RSC Chem Biol, 4(9):670-674(2023) [pubmed] |
Keyword List
| submitter keyword: Cisplatin-binding sites, Proteomics |
Contact List
| Chu Wang | |
|---|---|
| contact affiliation | Peking University |
| contact email | chuwang@pku.edu.cn |
| lab head | |
| Xianghe Wang | |
| contact affiliation | Peking University |
| contact email | waleywang@pku.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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