PXD043629
PXD043629 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Discovery of Cisplatin-binding Proteins by Competitive Cysteinome Profiling |
Description | Cisplatin is a widely-used cancer metallodrug which induces cytotoxicity by targeting DNA and chelating cysteines in proteins. Here we applied a competitive activity-based protein profiling strategy to identify cisplatin-binding cysteines in cancer proteomes. A novel cisplatin target, MetAP1, was found and functionally validated to contribute to cisplatin’s cytotoxicity. |
HostingRepository | iProX |
AnnounceDate | 2023-07-08 |
AnnouncementXML | Submission_2024-05-27_21:29:30.259.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Xianghe Wang |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | trimethylated residue |
Instrument | Q Exactive; Q Exactive Plus |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2023-07-09 23:51:50 | ID requested | |
1 | 2023-07-09 23:51:57 | announced | |
⏵ 2 | 2024-05-27 21:29:31 | announced | 2024-05-28: Update information. |
Publication List
Wang X, Zhang Y, Wang C, Discovery of cisplatin-binding proteins by competitive cysteinome profiling. RSC Chem Biol, 4(9):670-674(2023) [pubmed] |
Keyword List
submitter keyword: Cisplatin-binding sites, Proteomics |
Contact List
Chu Wang | |
---|---|
contact affiliation | Peking University |
contact email | chuwang@pku.edu.cn |
lab head | |
Xianghe Wang | |
contact affiliation | Peking University |
contact email | waleywang@pku.edu.cn |
dataset submitter |
Full Dataset Link List
iProX dataset URI |