PXD043620 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Deciphering how viral epitranscriptome shapes host immune response 1 |
Description | As early as 24 hours after RNA virus infection, up to 25% of all RNA molecules present in host cells are pathogenic viral RNA (vRNA), i.e. viral messenger RNA (vmRNA), viral genomic RNA (vgRNA), and double stranded replication intermediates (dsRNA). To prevent such a takeover of the host metabolism, the innate immune system of the infected organism must detect threat as soon as possible. When considering RNA viruses recognition, activation of timely proper immune response capable of sensing and neutralizing viral genetic material is crucial for cell survival. Viral nucleic acids are one of the strongest pathogen-associated molecular patterns (PAMPs), molecules causing particular immune system reactions. Human cells are armed with a variety of pattern recognition receptors (PRRs) responsible for PAMPs recognition. The main factors responsible for detecting foreign nucleic acids in mammalian cells have already been identified. For activation of any RNA sensor, detecting an abnormal molecular RNA pattern, not present under normal conditions, is obligatory. These patterns may be some chemical modification of RNA, or the absence of such one, specific secondary or tertiary RNA structure, particular sequence, or dsRNA that can derive from viral genome as it is in the case of dsRNA viruses or from annealed complementary RNA strands, which are generated as RNA virus replication intermediates. However, yet there is still very limited understanding of how different epitranscriptomic marks modulate host immune response. Therefore, we will attempt to comprehensively understand how chemical modifications of viral RNA influence its immunogenic potential and stability in infected cells. Moreover, we will study how epitranscriptomic marks deposited on viral RNAs shield transcripts from being recognized by host antiviral factors. |
HostingRepository | PRIDE |
AnnounceDate | 2025-03-17 |
AnnouncementXML | Submission_2025-03-17_04:07:58.587.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Dominik Cysewski |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion ETD |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-07-08 12:40:04 | ID requested | |
⏵ 1 | 2025-03-17 04:07:58 | announced | |
Publication List
Keyword List
submitter keyword: vmRNA, PRRs,AP-MS, vgRNA |
Contact List
Pawel Sikorski |
contact affiliation | Head of Laboratory of Epitranscriptomics Faculty of Biology, Biological and Chemical Research Centre, University of Warsaw, Poland |
contact email | pawelsikorski@uw.edu.pl |
lab head | |
Dominik Cysewski |
contact affiliation | Medical University of Bialystok |
contact email | dominikcysewski@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD043620
- Label: PRIDE project
- Name: Deciphering how viral epitranscriptome shapes host immune response 1