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PXD043620

PXD043620 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleDeciphering how viral epitranscriptome shapes host immune response 1
DescriptionAs early as 24 hours after RNA virus infection, up to 25% of all RNA molecules present in host cells are pathogenic viral RNA (vRNA), i.e. viral messenger RNA (vmRNA), viral genomic RNA (vgRNA), and double stranded replication intermediates (dsRNA). To prevent such a takeover of the host metabolism, the innate immune system of the infected organism must detect threat as soon as possible. When considering RNA viruses recognition, activation of timely proper immune response capable of sensing and neutralizing viral genetic material is crucial for cell survival. Viral nucleic acids are one of the strongest pathogen-associated molecular patterns (PAMPs), molecules causing particular immune system reactions. Human cells are armed with a variety of pattern recognition receptors (PRRs) responsible for PAMPs recognition. The main factors responsible for detecting foreign nucleic acids in mammalian cells have already been identified. For activation of any RNA sensor, detecting an abnormal molecular RNA pattern, not present under normal conditions, is obligatory. These patterns may be some chemical modification of RNA, or the absence of such one, specific secondary or tertiary RNA structure, particular sequence, or dsRNA that can derive from viral genome as it is in the case of dsRNA viruses or from annealed complementary RNA strands, which are generated as RNA virus replication intermediates. However, yet there is still very limited understanding of how different epitranscriptomic marks modulate host immune response. Therefore, we will attempt to comprehensively understand how chemical modifications of viral RNA influence its immunogenic potential and stability in infected cells. Moreover, we will study how epitranscriptomic marks deposited on viral RNAs shield transcripts from being recognized by host antiviral factors.
HostingRepositoryPRIDE
AnnounceDate2025-03-17
AnnouncementXMLSubmission_2025-03-17_04:07:58.587.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterDominik Cysewski
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion ETD
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-07-08 12:40:04ID requested
12025-03-17 04:07:58announced
Publication List
10.1126/SCIADV.ADS6498;
Keyword List
submitter keyword: vmRNA, PRRs,AP-MS, vgRNA
Contact List
Pawel Sikorski
contact affiliationHead of Laboratory of Epitranscriptomics Faculty of Biology, Biological and Chemical Research Centre, University of Warsaw, Poland
contact emailpawelsikorski@uw.edu.pl
lab head
Dominik Cysewski
contact affiliationMedical University of Bialystok
contact emaildominikcysewski@gmail.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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