PXD043604

PXD043604 is an original dataset announced via ProteomeXchange.

Title	Assessment of the effect of 21-day head-down bed rest on the cardiovascular system by blood protein composition, including markers sST2, NT-proBNP and D-dimer
Description	Head-down bed rest (HDBR) is one of the models of the physiological effects of weightlessness used, among other things, to assess the effect of hypokinesia on the physiological systems of the human body and, first of all, on the cardiovascular system. The aim of the work was to study the effect of 21-day HDBR factors on the cardiovascular system based on blood proteomic profile data and myocardial stress biomarkers sST2, NT-proBNP, and the thrombogenesis risk marker D-dimer. It was revealed that HDBR conditions led to an increase in the level of proteins of the complement and the coagulation cascade systems, platelet degranulation, fibrinolysis, acute phase proteins, post-translational modification of proteins, retinol-binding protein 4 (RBP4), apolipoprotein B, S100A8, associated with cardiovascular diseases, and other proteins that affect the functions of endothelial cells. It has been shown that the level of proteins in the blood involved in the remodeling of the cytoskeleton, oxygen transport, heme catabolism, etc. decreased during HDBR. A significant decrease in the levels of NT-proBNP and sST2 by the 21st day of HDBR and a rapid recovery of their levels already on the first day of the rehabilitation period was established, which indicated the restoration of hemodynamic parameters of the heart function. The levels of D-dimer in different periods of the experiment and after its completion (on the 14th day) did not differ from the background values, which indicated the absence of the risk of thrombosis during this exposure and within 14 days after its completion.
HostingRepository	PRIDE
AnnounceDate	2026-07-01
AnnouncementXML	Submission_2026-07-01_02:49:49.642.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Alexander Brzhozovskiy
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Bruker Daltonics timsTOF series

Revision	Datetime	Status	ChangeLog Entry
0	2023-07-07 05:35:43	ID requested
⏵ 1	2026-07-01 02:49:50	announced

10.3389/fphys.2024.1375929;

Kashirina DN, Pastushkova LK, Goncharova AG, Larina IM, Assessment of the effect of 21-day head-down bed rest on the cardiovascular system by blood protein composition. Front Physiol, 15():1375929(2024) [pubmed]

submitter keyword: head-down bed rest, mass spectrometry, NT-proBNP, D-dimer, sST2

Irina Larina
contact affiliation	Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia
contact email	irina.larina@gmail.com
lab head
Alexander Brzhozovskiy
contact affiliation	V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of the Russian Federation, Moscow, Russia
contact email	agb.imbp@gmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD043604
     1. Label: PRIDE project
     2. Name: Assessment of the effect of 21-day head-down bed rest on the cardiovascular system by blood protein composition, including markers sST2, NT-proBNP and D-dimer