PXD043558

PXD043558 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Identifying the mechanism of platelet activation by platelet factor 4 (PF4) a.k.a CXCL4
Description	We discovered that platelets become activated by platelet factor 4 and have looked into how this is the case. We used phosphoproteomics to identify proteins that were phosphorylated in a band on a Western blot at 95 kDa and identified phospho STAT5. We have subsequently shown that PF4 activates platelets through the JAK/STAT pathway.
HostingRepository	PRIDE
AnnounceDate	2024-06-16
AnnouncementXML	Submission_2024-06-16_01:08:54.695.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD043558
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Richard Buka
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	Q Exactive HF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-07-05 07:34:31	ID requested
⏵ 1	2024-06-16 01:08:55	announced

Publication List

10.6019/PXD043558;
Buka RJ, Montague SJ, Moran LA, Martin EM, Slater A, Watson SP, Nicolson PLR, PF4 activates the c-Mpl-Jak2 pathway in platelets. Blood, 143(1):64-69(2024) [pubmed]
10.1182/blood.2023020872;

10.6019/PXD043558;

Buka RJ, Montague SJ, Moran LA, Martin EM, Slater A, Watson SP, Nicolson PLR, PF4 activates the c-Mpl-Jak2 pathway in platelets. Blood, 143(1):64-69(2024) [pubmed]

10.1182/blood.2023020872;

Keyword List

submitter keyword: Human, PF4, CXCL4, Signalling, Platelets

submitter keyword: Human, PF4, CXCL4, Signalling, Platelets

Contact List

Phillip L R Nicolson
contact affiliation	Institute of Cardiovascular Sciences University of Birmingham Birmingham B15 2TT
contact email	p.nicolson@bham.ac.uk
lab head
Richard Buka
contact affiliation	University of Birmingham
contact email	r.j.buka@bham.ac.uk
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/06/PXD043558
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/06/PXD043558

PRIDE project URI

Repository Record List

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