PXD043558
PXD043558 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Identifying the mechanism of platelet activation by platelet factor 4 (PF4) a.k.a CXCL4 |
| Description | We discovered that platelets become activated by platelet factor 4 and have looked into how this is the case. We used phosphoproteomics to identify proteins that were phosphorylated in a band on a Western blot at 95 kDa and identified phospho STAT5. We have subsequently shown that PF4 activates platelets through the JAK/STAT pathway. |
| HostingRepository | PRIDE |
| AnnounceDate | 2024-10-22 |
| AnnouncementXML | Submission_2024-10-22_06:45:30.488.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD043558 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Richard Buka |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | phosphorylated residue |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-07-05 07:34:31 | ID requested | |
| 1 | 2024-06-16 01:08:55 | announced | |
| ⏵ 2 | 2024-10-22 06:45:31 | announced | 2024-10-22: Updated project metadata. |
Publication List
| 10.6019/PXD043558; |
| Buka RJ, Montague SJ, Moran LA, Martin EM, Slater A, Watson SP, Nicolson PLR, PF4 activates the c-Mpl-Jak2 pathway in platelets. Blood, 143(1):64-69(2024) [pubmed] |
| 10.1182/blood.2023020872; |
Keyword List
| submitter keyword: Human, PF4, CXCL4, Signalling, Platelets |
Contact List
| Phillip L R Nicolson | |
|---|---|
| contact affiliation | Institute of Cardiovascular Sciences University of Birmingham Birmingham B15 2TT |
| contact email | p.nicolson@bham.ac.uk |
| lab head | |
| Richard Buka | |
| contact affiliation | University of Birmingham |
| contact email | r.j.buka@bham.ac.uk |
| dataset submitter | |
Full Dataset Link List
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/06/PXD043558 |
| PRIDE project URI |
Repository Record List
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