PXD043557

PXD043557 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Microglia polarization and anti-glioma effects fostered by dual cell membrane-coated doxorubicin-loaded hexagonal boron nitride nanoplatelets
Description	Glioblastoma multiforme (GBM) is a highly malignant brain cancer, and microglial cells play a critical role in its progression. Activation of microglia can either promote or inhibit GBM growth depending on the stage of tumour development and on the microenvironment. As current treatments for GBM have limited efficacy, there is an urgent need to develop novel strategies based on nanoplatforms for drug delivery and efficient targeting. This study investigated the microglial response and the therapeutic efficacy of dual cell membrane-coated and doxorubicin-loaded hexagonal boron nitride nanoplatelets, tested on human microglia and GBM cells. The results showed promising therapeutic effects on glioma cells and an M2 microglia polarization, highlighted through proteomic analysis.
HostingRepository	PRIDE
AnnounceDate	2024-01-26
AnnouncementXML	Submission_2024-01-26_10:19:32.391.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Martina Bartolucci
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-07-05 07:22:31	ID requested
⏵ 1	2024-01-26 10:19:33	announced

Publication List

10.1021/acsami.3c17097;
Ş, en Ö, Emanet M, Mazzuferi M, Bartolucci M, Catalano F, Prato M, Moscato S, Marino A, De Pasquale D, Pugliese G, Bonaccorso F, Pellegrini V, Castillo AEDR, Petretto A, Ciofani G, Microglia Polarization and Antiglioma Effects Fostered by Dual Cell Membrane-Coated Doxorubicin-Loaded Hexagonal Boron Nitride Nanoflakes. ACS Appl Mater Interfaces, 15(50):58260-58273(2023) [pubmed]

10.1021/acsami.3c17097;

Ş, en Ö, Emanet M, Mazzuferi M, Bartolucci M, Catalano F, Prato M, Moscato S, Marino A, De Pasquale D, Pugliese G, Bonaccorso F, Pellegrini V, Castillo AEDR, Petretto A, Ciofani G, Microglia Polarization and Antiglioma Effects Fostered by Dual Cell Membrane-Coated Doxorubicin-Loaded Hexagonal Boron Nitride Nanoflakes. ACS Appl Mater Interfaces, 15(50):58260-58273(2023) [pubmed]

Keyword List

submitter keyword: glioblastoma multiforme
microglia
M2 polarization
hexagonal boron nitride nanoplatelets
homotypic targeting
doxorubicin

submitter keyword: glioblastoma multiforme

microglia

M2 polarization

hexagonal boron nitride nanoplatelets

homotypic targeting

doxorubicin

Contact List

Andrea Petretto
contact affiliation	IRCCS Istituto G Gaslini
contact email	a.petretto@gmail.com
lab head
Martina Bartolucci
contact affiliation	IRCCS Gaslini
contact email	smartibartolucci@gmail.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/01/PXD043557
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/01/PXD043557

PRIDE project URI

Repository Record List

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