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PXD043551

PXD043551 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMass spectrometry-based profiling of histone posttranslational modifications in uveal melanoma tissue, human melanocytes, and uveal melanoma cell lines
DescriptionPurpose: Epigenetic mechanisms and alterations in uveal melanoma (UM) development are still not well understood. In this pilot study, histone posttranslational modifications (PTMs), which are epigenetic mechanisms regulating gene expression, were analyzed in UM formalin-fixed paraffin-embedded (FFPE) tissues and control tissue as well as in UM cell lines and healthy melanocytes to provide a deeper insight into the pathogenesis of UM and the potentially prognostic relevance of these molecular markers. Methods: FFPE tissue of UM (n=24) and normal choroid (n=4) as well as human UM cell lines (n=7), human skin melanocytes (n=6) and uveal melanocytes (n=2), were analyzed by a quantitative mass spectrometry (MS) approach.
HostingRepositoryPRIDE
AnnounceDate2024-02-14
AnnouncementXMLSubmission_2024-02-14_04:41:54.035.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterRoberta Noberini
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonomethylated residue; trimethylated residue; acetylated residue; dimethylated residue
InstrumentQ Exactive Plus
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-07-05 02:46:30ID requested
12024-02-14 04:41:54announced
Publication List
10.1167/IOVS.65.2.27;
Keyword List
submitter keyword: histone posttranslational modifications, uveal melanoma
Contact List
Tiziana Bonaldi
contact affiliationEuropean Institute of Oncology, Milan
contact emailtiziana.bonaldi@ieo.it
lab head
Roberta Noberini
contact affiliationIstituto Europeo di Oncologia
contact emailroberta.noberini@ieo.it
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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