PXD043550

PXD043550 is an original dataset announced via ProteomeXchange.

Title	Mouse and Human Conjunctiva Organoids to Study Ocular Surface Homeostasis and Disease
Description	The conjunctival epithelium covering the eye consists of two main differentiated cell types: mucus-producing Goblet cells and ‘keratinocytes’ of unknown function. Here, we describe long-term expanding organoids representing human conjunctiva. To check if interleukins may boost secretome expression, we stimulated the organoid cells with pleiotropic anti-inflammatory cytokines interleukin-4 and IL-13. Secretions were identified by shotgun MS to quantitatively enriched secreted proteins.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:20:30.785.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ziliang Ma
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Eclipse

Revision	Datetime	Status	ChangeLog Entry
0	2023-07-05 02:43:30	ID requested
1	2024-01-11 09:53:41	announced
⏵ 2	2024-10-22 06:20:31	announced	2024-10-22: Updated project metadata.

10.1016/J.STEM.2023.12.008;

submitter keyword: Organoids,Conjunctiva, Proteomics, Secretome

Wei Wu
contact affiliation	Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), 138648 Singapore, Singapore. Department of Pharmacy, National University of Singapore, 117543, Singapore, Singapore.
contact email	w.wu1@uu.nl
lab head
Ziliang Ma
contact affiliation	Utrecht University
contact email	z.ma@uu.nl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/01/PXD043550

PRIDE project URI

• PRIDE
  1. PXD043550
     1. Label: PRIDE project
     2. Name: Mouse and Human Conjunctiva Organoids to Study Ocular Surface Homeostasis and Disease