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PXD043546

PXD043546 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleCrosstalk between pentraxin-3 and humoral pattern-recognition receptors plays an essential role in immunomodulation against Aspergillus fumigatus
DescriptionThe study investigated the interaction between pentraxin-3 (PTX3), a soluble pattern-recognition receptor, and the fungal pathogen Aspergillus fumigatus. The aim was to identify the ligands for PTX3 and the impact of PTX3 on the immune response. A. fumigatus spores, hyphae or cell wall components were incubated with PTX3, human serum and others humoral factors and their interaction was studied by immunofluorescence, flow cytometry and ELISA. Opsonizd conidia were co-incubated with human monocyte-derived macrophages (hMDM) and cytokine secretion was measured.
HostingRepositoryPRIDE
AnnounceDate2024-08-02
AnnouncementXMLSubmission_2024-08-02_08:21:02.936.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterThomas Krüger
SpeciesList scientific name: Neosartorya fumigata (Aspergillus fumigatus); NCBI TaxID: 746128;
ModificationListphosphorylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Exploris 480
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-07-05 01:59:40ID requested
12024-08-02 08:21:03announced
Publication List
10.1038/S41467-024-51047-9;
Keyword List
submitter keyword: humoral immunity, surfactant protein D,Aspergillus fumigatus, pentraxin-3, C1q, C3b
Contact List
Axel A. Brakhage
contact affiliationDepartment of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute Jena (Leibniz-HKI)
contact emailaxel.brakhage@leibniz-hki.de
lab head
Thomas Krüger
contact affiliationLeibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute
contact emailthomas.krueger@leibniz-hki.de
dataset submitter
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Dataset FTP location
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