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PXD043531

PXD043531 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleA deep XL-proteomic dataset of intact HEK293T cells using DSBSO
DescriptionCross-linking mass spectrometry is an emerging method to study protein-protein interactions (PPIs) in intact biological systems. Here, we optimized a workflow for gnerating high coverage maps of PPIs using the enrichable cross-linker Azide-A-DSBSO. This created one of the largest to-date XL-MS datasets, enabling structural characterization of thousands of PPIs in their intact subcellular environment.
HostingRepositoryPRIDE
AnnounceDate2024-10-17
AnnouncementXMLSubmission_2024-10-17_02:26:20.102.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterBoris Bogdanow
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-07-04 05:05:09ID requested
12024-10-17 02:26:20announced
Publication List
10.1038/S41592-024-02478-1;
Keyword List
submitter keyword: Human, deep XL-MS, Cell Culture
Contact List
Fan Liu
contact affiliationLeibniz-Institute for Molecular Pharmacology (FMP)
contact emailfliu@fmp-berlin.de
lab head
Boris Bogdanow
contact affiliationLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)
contact emailbogdanow@fmp-berlin.de
dataset submitter
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Dataset FTP location
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PRIDE project URI
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