PXD043531

PXD043531 is an original dataset announced via ProteomeXchange.

Title	A deep XL-proteomic dataset of intact HEK293T cells using DSBSO
Description	Cross-linking mass spectrometry is an emerging method to study protein-protein interactions (PPIs) in intact biological systems. Here, we optimized a workflow for gnerating high coverage maps of PPIs using the enrichable cross-linker Azide-A-DSBSO. This created one of the largest to-date XL-MS datasets, enabling structural characterization of thousands of PPIs in their intact subcellular environment.
HostingRepository	PRIDE
AnnounceDate	2024-10-17
AnnouncementXML	Submission_2024-10-17_02:26:20.102.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Boris Bogdanow
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2023-07-04 05:05:09	ID requested
⏵ 1	2024-10-17 02:26:20	announced

10.1038/S41592-024-02478-1;

submitter keyword: Human, deep XL-MS, Cell Culture

Fan Liu
contact affiliation	Leibniz-Institute for Molecular Pharmacology (FMP)
contact email	fliu@fmp-berlin.de
lab head
Boris Bogdanow
contact affiliation	Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)
contact email	bogdanow@fmp-berlin.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD043531

PRIDE project URI

• PRIDE
  1. PXD043531
     1. Label: PRIDE project
     2. Name: A deep XL-proteomic dataset of intact HEK293T cells using DSBSO