PXD043516 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Discovering radiation biomarkers in plasma of total-body irradiated leukemia patients |
| Description | The population's increasing risk of acute large-scale radiological/nuclear exposures underlines the need for functional radiation biomarkers. As ionizing radiation triggers a complex response on the genome, proteome, and metabolome level, all were already reported as suitable indicators of radiation-induced damage in vitro or in animal models. We aim to analyze the blood of total-body irradiated (TBI) leukaemia patients using a mass spectrometry approach and to identify and quantify plasma proteins before and after irradiation. Combining two independent mass spectrometry approaches we identified 15 plasma proteins differing in the blood of TBI patients before and after irradiation. The majority of proteins were associated with the inflammatory responce of the immune system and with metabolism of lipids. These candidate radiation biomarkers might have implications for practical biological dosimetry. |
| HostingRepository | PRIDE |
| AnnounceDate | 2024-10-22 |
| AnnouncementXML | Submission_2024-10-22_06:45:55.619.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD043516 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Pavel Rehulka |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2023-07-03 17:18:03 | ID requested | |
| 1 | 2024-06-16 02:19:48 | announced | |
| ⏵ 2 | 2024-10-22 06:45:57 | announced | 2024-10-22: Updated project metadata. |
Publication List
| 10.1667/rade-23-00137.1; |
| 10.6019/PXD043516; |
| Gabriela R, Vera V, Pavel R, Helena R, Igor S, Marie D, Marketa M, Alena MF, Ales T, Discovering the Radiation Biomarkers in the Plasma of Total-Body Irradiated Leukemia Patients. Radiat Res, 201(5):418-428(2024) [pubmed] |
Keyword List
| submitter keyword: proteomics,Human plasma, irradiation, biomarkers |
Contact List
| Ales Tichy |
|---|
| contact affiliation | Head of Radiation Pathology Group Deputy Head of Department of Radiobiology Faculty of Military Health Sciences University of Defence Třebešská 1575 500 01 Hradec Králové Czech Republic Phone: +420 973 253 216 Cell: +420 775 966 691 Email: ales.tichy@unob.cz Web:http://www.unob.cz |
| contact email | ales.tichy@unob.cz |
| lab head | |
| Pavel Rehulka |
|---|
| contact affiliation | Department of Molecular Pathology and Biology FMHS UD, Trebesska 1575, CZ-50001 Hradec Kralove, Czech Republic |
| contact email | pavel.rehulka@unob.cz |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/06/PXD043516 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD043516
- Label: PRIDE project
- Name: Discovering radiation biomarkers in plasma of total-body irradiated leukemia patients
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