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PXD043516

PXD043516 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleDiscovering radiation biomarkers in plasma of total-body irradiated leukemia patients
DescriptionThe population's increasing risk of acute large-scale radiological/nuclear exposures underlines the need for functional radiation biomarkers. As ionizing radiation triggers a complex response on the genome, proteome, and metabolome level, all were already reported as suitable indicators of radiation-induced damage in vitro or in animal models. We aim to analyze the blood of total-body irradiated (TBI) leukaemia patients using a mass spectrometry approach and to identify and quantify plasma proteins before and after irradiation. Combining two independent mass spectrometry approaches we identified 15 plasma proteins differing in the blood of TBI patients before and after irradiation. The majority of proteins were associated with the inflammatory responce of the immune system and with metabolism of lipids. These candidate radiation biomarkers might have implications for practical biological dosimetry.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_06:45:55.619.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD043516
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterPavel Rehulka
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-07-03 17:18:03ID requested
12024-06-16 02:19:48announced
22024-10-22 06:45:57announced2024-10-22: Updated project metadata.
Publication List
10.1667/rade-23-00137.1;
10.6019/PXD043516;
Gabriela R, Vera V, Pavel R, Helena R, Igor S, Marie D, Marketa M, Alena MF, Ales T, Discovering the Radiation Biomarkers in the Plasma of Total-Body Irradiated Leukemia Patients. Radiat Res, 201(5):418-428(2024) [pubmed]
Keyword List
submitter keyword: proteomics,Human plasma, irradiation, biomarkers
Contact List
Ales Tichy
contact affiliationHead of Radiation Pathology Group Deputy Head of Department of Radiobiology Faculty of Military Health Sciences University of Defence Třebešská 1575 500 01 Hradec Králové Czech Republic Phone: +420 973 253 216 Cell: +420 775 966 691 Email: ales.tichy@unob.cz Web:http://www.unob.cz
contact emailales.tichy@unob.cz
lab head
Pavel Rehulka
contact affiliationDepartment of Molecular Pathology and Biology FMHS UD, Trebesska 1575, CZ-50001 Hradec Kralove, Czech Republic
contact emailpavel.rehulka@unob.cz
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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