PXD043480

PXD043480 is an original dataset announced via ProteomeXchange.

Title	Placental proteomics identified elevated Aldo-keto Reductase 1-B1 level in spontaneous preterm birth
Description	The prevalence of preterm birth along with its associated mortality and lifelong morbidity warrant a better understanding of the underlying signaling events for better diagnosis and management of the condition. Placenta is an important transient organ that acts as a conduit between the fetus and mother. Any physiological and pathological changes taking place in the feto-maternal system are directly reflected in the placenta, making it a fitting choice to study the altered signaling mechanisms that are play. We undertook independent data acquisition of clinical placenta samples (n=40), obtained from Garbh-Ini cohort, to study their comparative protein profiles in spontaneous preterm vs term birth condition. When label-free quantitation (LFQ) was carried out, it yielded 23 differentially expressed proteins (DEPs) in the case-control comparison.
HostingRepository	PRIDE
AnnounceDate	2025-01-31
AnnouncementXML	Submission_2025-01-30_23:49:11.861.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	TUSHAR KANTI MAITI
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2023-07-03 03:38:40	ID requested
⏵ 1	2025-01-30 23:49:12	announced

10.1021/ACS.JPROTEOME.4C00698;

submitter keyword: AKR1B1,Spontaneous preterm birth, parturition, label-free quantification (LFQ), PGF2α, independent data acquisition (IDA), placenta

Dr. Tushar Kanti Maiti
contact affiliation	Professor, Regional Centre for Biotechnology NCR Biotech Science Cluster 3rd Milestone, Faridabad-Gurgaon Expressway Faridabad-121001, Haryana INDIA
contact email	tkmaiti@rcb.res.in
lab head
TUSHAR KANTI MAITI
contact affiliation	Regional Centre for Biotechnology
contact email	tkmaiti@rcb.res.in
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD043480
     1. Label: PRIDE project
     2. Name: Placental proteomics identified elevated Aldo-keto Reductase 1-B1 level in spontaneous preterm birth