PXD043426

PXD043426 is an original dataset announced via ProteomeXchange.

Title	Streptococcus agalactiae and Prototheca spp. infections induce changes in milk peptidome in Holstein cattle
Description	Early detection of bovine subclinical mastitis may improve treatment strategies and reduce the use of antibiotics. Herein, individual milk samples from Holstein cows affected by subclinical mastitis induced by S. agalactiae and Prototheca spp. were analyzed by untargeted and targeted mass spectrometry approaches to assess changes in their peptidome profiles and identify new potential biomarkers of the pathological condition. Results showed a higher amount of peptides in milk positive at the bacteriological examination when compared with the negative control. However, the different pathogens seemed not to trigger specific effects on milk peptidome. The peptides that best distinguish positive from negative samples are mainly derived from the most abundant milk proteins, especially from β- and αs1-casein, but also include the antimicrobial peptide casecidin 17. These results provide new insights into the physiopathology of mastitis. Upon further validation, the panel of potential discriminant peptides could help to the development of new diagnostic and therapeutic tools.
HostingRepository	PRIDE
AnnounceDate	2024-01-26
AnnouncementXML	Submission_2024-01-26_09:45:33.814.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Giorgio Arrigoni
SpeciesList	scientific name: Bos taurus (Bovine); NCBI TaxID: 9913;
ModificationList	No PTMs are included in the dataset
Instrument	TSQ Quantiva; LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2023-06-30 04:29:58	ID requested
⏵ 1	2024-01-26 09:45:34	announced

Vanzin A, Franchin C, Arrigoni G, Battisti I, Masi A, Squartini A, Bisutti V, Giannuzzi D, Gallo L, Cecchinato A, Pegolo S, spp. Induces Changes in Milk Peptidome in Holstein Cattle. J Agric Food Chem, 71(44):16827-16839(2023) [pubmed]

10.1021/acs.jafc.3c03065;

submitter keyword: milk endogenous peptides, mass spectrometry, Streptococcus agalactiae,Udder health, Prototheca spp.

Giorgio Arrigoni
contact affiliation	Department of Biomedical Sciences, University of Padova, ITALY
contact email	giorgio.arrigoni@unipd.it
lab head
Giorgio Arrigoni
contact affiliation	University of Padova
contact email	giorgio.arrigoni74@gmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD043426
     1. Label: PRIDE project
     2. Name: Streptococcus agalactiae and Prototheca spp. infections induce changes in milk peptidome in Holstein cattle