PXD043414

PXD043414 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Unbiased phosphoproteomics analysis of human myotubes unveils extramitotic CDK1 kinase activity modulates insulin signaling
Description	We performed total proteome and phosphoproteome analysis to characterize the role of non-mitotic kinase activity of CDK1 in insulin signaling through pharmacological inhibition and translational repression via siRNA-based knockdown. Specifically, cultured myotubes were treated with RO-3306, a selective ATP competitive inhibitor to inhibit CDK1 activity, or transfected with a CDK1 targeting siRNA pool to decrease CDK1 expression.
HostingRepository	jPOST
AnnounceDate	2024-07-04
AnnouncementXML	Submission_2024-07-03_08:00:08.158.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD043414
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Radoslaw Sobota
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	S-carboxamidomethyl-L-cysteine; alpha-amino acetylated residue; L-methionine sulfoxide; O-phospho-L-serine; O-phospho-L-threonine; O4'-phospho-L-tyrosine; deamidated L-asparagine; deamidated L-glutamine
Instrument	instrument

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-06-29 23:45:32	ID requested
⏵ 1	2024-07-03 08:00:08	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: human, myotube, insulin, phosphoproteomics

submitter keyword: human, myotube, insulin, phosphoproteomics

Contact List

E Shyong Tai
lab head
Radoslaw Sobota
contact affiliation	IMCB A-STAR Singapore
dataset submitter

Full Dataset Link List

jPOST dataset URI
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jPOST dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST002220/