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PXD043410

PXD043410 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleTandem mass tag-based proteomic profiling of drainage fluid
DescriptionAnastomotic leakage (AL), one of the most severe complications in rectal surgery, is often diagnosed late because of the low specificity of clinical symptoms and limitations of current clinical investigations. Identification of patients with early AL remains challenging. Here, we explored the protein expression profiles of AL patients to provide potential biomarkers to predict AL in patients who undergo surgery for rectal cancer. We screened differentially expressed proteins (DEPs) in drainage fluid from AL and non-AL patients using a tandem mass tag (TMT) method. A total of 248 DEPs, including 98 upregulated and 150 downregulated proteins, were identified between AL and non-AL groups.
HostingRepositoryiProX
AnnounceDate2023-06-29
AnnouncementXMLSubmission_2024-05-29_20:59:39.692.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterXiangqian Su
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-06-29 19:47:23ID requested
12023-06-29 19:47:42announced
22024-05-29 20:59:40announced2024-05-30: Update information.
Publication List
Qiao X, Qi X, Xing P, Liu T, Hao H, Yang X, Jiang B, Cui M, Su X, Tandem Mass Tag-Based Proteomic Profiling Identifies Biomarkers in Drainage Fluid for Early Detection of Anastomotic Leakage after Rectal Cancer Resection. J Proteome Res, 22(11):3559-3569(2023) [pubmed]
Keyword List
submitter keyword: Human, drainage fluid, LC-MS
Contact List
Xiangqian Su
contact affiliationPeking University Cancer Hospital & Institute
contact emailsuxiangqian@bjmu.edu.cn
lab head
Xiangqian Su
contact affiliationPeking University Cancer Hospital & Institute
contact emailsuxiangqian@bjmu.edu.cn
dataset submitter
Full Dataset Link List
iProX dataset URI