PXD043410

PXD043410 is an original dataset announced via ProteomeXchange.

Title	Tandem mass tag-based proteomic profiling of drainage fluid
Description	Anastomotic leakage (AL), one of the most severe complications in rectal surgery, is often diagnosed late because of the low specificity of clinical symptoms and limitations of current clinical investigations. Identification of patients with early AL remains challenging. Here, we explored the protein expression profiles of AL patients to provide potential biomarkers to predict AL in patients who undergo surgery for rectal cancer. We screened differentially expressed proteins (DEPs) in drainage fluid from AL and non-AL patients using a tandem mass tag (TMT) method. A total of 248 DEPs, including 98 upregulated and 150 downregulated proteins, were identified between AL and non-AL groups.
HostingRepository	iProX
AnnounceDate	2023-06-29
AnnouncementXML	Submission_2024-05-29_20:59:39.692.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xiangqian Su
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-06-29 19:47:23	ID requested
1	2023-06-29 19:47:42	announced
⏵ 2	2024-05-29 20:59:40	announced	2024-05-30: Update information.

Qiao X, Qi X, Xing P, Liu T, Hao H, Yang X, Jiang B, Cui M, Su X, Tandem Mass Tag-Based Proteomic Profiling Identifies Biomarkers in Drainage Fluid for Early Detection of Anastomotic Leakage after Rectal Cancer Resection. J Proteome Res, 22(11):3559-3569(2023) [pubmed]

submitter keyword: Human, drainage fluid, LC-MS

Xiangqian Su
contact affiliation	Peking University Cancer Hospital & Institute
contact email	suxiangqian@bjmu.edu.cn
lab head
Xiangqian Su
contact affiliation	Peking University Cancer Hospital & Institute
contact email	suxiangqian@bjmu.edu.cn
dataset submitter

iProX dataset URI