PXD043333 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Oncogene EVI1 Drives Acute Myeloid Leukemia Via a Targetable Interaction with CTBP2 |
Description | Acute myeloid leukemia (AML) driven by the activation of EVI1 due to chromosome 3q26/MECOM rearrangements is incurable with current chemotherapy regimens. Insight into the mechanism by which EVI1 drives myeloid transformation is needed to target EVI1 in those leukemias. Here we demonstrate recurrent interaction of CTBP1/2 with a unique PLDLS motif in EVI1, which is indispensable for leukemic transformation of 3q26/MECOM rearranged AML. A PLDLS competitor construct outcompetes EVI1 to CTBP1/2 binding and inhibits AML proliferation in xenotransplant models. This proof-of-concept study opens the possibility to target one of the most incurable forms of AML using specific inhibitors directed to EVI1/CTBP1/2 interaction. Our findings have important implications for other tumour types with aberrant expression of EVI1 or other oncogenic transcription factors that also depend on CTBP1/2 interaction. |
HostingRepository | PRIDE |
AnnounceDate | 2023-07-13 |
AnnouncementXML | Submission_2023-07-13_02:22:01.956.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | JeroenDemmers |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-06-27 01:00:12 | ID requested | |
⏵ 1 | 2023-07-13 02:22:02 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: CTBP2, Acute Myeloid Leukemia (AML),EVI1, interactomics |
Contact List
JeroenDemmers |
contact affiliation | Erasmus MC |
contact email | j.demmers@erasmusmc.nl |
lab head | |
JeroenDemmers |
contact affiliation | Proteomics Center, Erasmus University Medical Center, Rotterdam, The Netherlands |
contact email | j.demmers@erasmusmc.nl |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD043333 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD043333
- Label: PRIDE project
- Name: Oncogene EVI1 Drives Acute Myeloid Leukemia Via a Targetable Interaction with CTBP2