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PXD043296

PXD043296 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleInflammatory microenvironment in immunometabolic-compromised treated HIV infection steered synaptic dysregulation
DescriptionMulti-omics data-driven personalized health profiling can provide valuable insight into metabolic perturbations in people living with HIV (PWH) under successful antiretroviral therapy (ART). We integrated transcriptomics, proteomics, and metabolomics to identify and stratify the immunometabolically compromised treated PWH (n=158). Based on clinical and lifestyle data, 44% (70/158) of PWH were at risk of immunometabolic complications. We identified six plasma biomarkers to define the at-risk phenotype using advanced machine learning and a Bayesian classifier that drives a network of proteins reasoned for monocyte immunosenescence. We identified metabolic perturbations driven by central carbon metabolic flux led to chronic monocyte activation impairing its early functional properties. Further, we discovered that the host-induced spermidine-mediated microenvironment was responsible for chronic inflammation leading to synaptic dysregulation in vitro, potentiating the risk of neuropsychiatric clinical phenotypes in the at-risk PWH. Novel intervention targeting metabolically-perturbed chronic inflammatory conditions can lead to healthier aging in the at-risk PWH.
HostingRepositoryPRIDE
AnnounceDate2025-05-06
AnnouncementXMLSubmission_2025-05-06_09:39:58.708.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAkos Vegvari
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListiodoacetamide derivatized residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-06-26 03:30:24ID requested
12025-05-06 09:39:59announced
Publication List
Mikaeloff F, Gelpi M, Esc, ó, s A, Wang T, Gupta S, Olofsson A, Akusj, ä, rvi SS, Schuster S, Naval P, Sood V, Nikouyan N, Knudsen AD, Vestad B, H, ø, gh J, Hov JR, Benfield T, Tr, ø, seid M, Pawar V, Rucevic M, Benfeitas R, V, é, gv, á, ri Á, O'Mahony L, Savai R, Bj, ö, rkstr, ö, m NK, Lourda M, de Magalh, ã, es JP, Weiss S, Mardinoglu A, Varshney MK, Karlsson AC, Syed YA, Nielsen SD, Neogi U, Host Plasma Microenvironment in Immunometabolically Impaired HIV Infection Leads to Dysregulated Monocyte Function and Synaptic Transmission Ex Vivo. Adv Sci (Weinh), 12(16):e2416453(2025) [pubmed]
10.1002/advs.202416453;
Keyword List
submitter keyword: multi-omics,antiretroviral therapy
Contact List
Akos Vegvari
contact affiliationKarolinska Insitutet
contact emailakos.vegvari@ki.se
lab head
Akos Vegvari
contact affiliationKarolinska Institutet
contact emailakos.vegvari@ki.se
dataset submitter
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Dataset FTP location
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