PXD043296

PXD043296 is an original dataset announced via ProteomeXchange.

Title	Inflammatory microenvironment in immunometabolic-compromised treated HIV infection steered synaptic dysregulation
Description	Multi-omics data-driven personalized health profiling can provide valuable insight into metabolic perturbations in people living with HIV (PWH) under successful antiretroviral therapy (ART). We integrated transcriptomics, proteomics, and metabolomics to identify and stratify the immunometabolically compromised treated PWH (n=158). Based on clinical and lifestyle data, 44% (70/158) of PWH were at risk of immunometabolic complications. We identified six plasma biomarkers to define the at-risk phenotype using advanced machine learning and a Bayesian classifier that drives a network of proteins reasoned for monocyte immunosenescence. We identified metabolic perturbations driven by central carbon metabolic flux led to chronic monocyte activation impairing its early functional properties. Further, we discovered that the host-induced spermidine-mediated microenvironment was responsible for chronic inflammation leading to synaptic dysregulation in vitro, potentiating the risk of neuropsychiatric clinical phenotypes in the at-risk PWH. Novel intervention targeting metabolically-perturbed chronic inflammatory conditions can lead to healthier aging in the at-risk PWH.
HostingRepository	PRIDE
AnnounceDate	2025-05-06
AnnouncementXML	Submission_2025-05-06_09:39:58.708.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Akos Vegvari
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-06-26 03:30:24	ID requested
⏵ 1	2025-05-06 09:39:59	announced

Mikaeloff F, Gelpi M, Esc, ó, s A, Wang T, Gupta S, Olofsson A, Akusj, ä, rvi SS, Schuster S, Naval P, Sood V, Nikouyan N, Knudsen AD, Vestad B, H, ø, gh J, Hov JR, Benfield T, Tr, ø, seid M, Pawar V, Rucevic M, Benfeitas R, V, é, gv, á, ri Á, O'Mahony L, Savai R, Bj, ö, rkstr, ö, m NK, Lourda M, de Magalh, ã, es JP, Weiss S, Mardinoglu A, Varshney MK, Karlsson AC, Syed YA, Nielsen SD, Neogi U, Host Plasma Microenvironment in Immunometabolically Impaired HIV Infection Leads to Dysregulated Monocyte Function and Synaptic Transmission Ex Vivo. Adv Sci (Weinh), 12(16):e2416453(2025) [pubmed]

10.1002/advs.202416453;

submitter keyword: multi-omics,antiretroviral therapy

Akos Vegvari
contact affiliation	Karolinska Insitutet
contact email	akos.vegvari@ki.se
lab head
Akos Vegvari
contact affiliation	Karolinska Institutet
contact email	akos.vegvari@ki.se
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD043296
     1. Label: PRIDE project
     2. Name: Inflammatory microenvironment in immunometabolic-compromised treated HIV infection steered synaptic dysregulation