PXD043294

PXD043294 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Exploring the Spatial Landscape of the Estrogen Receptor Proximal Proteome With Antibody-Based Proximity Labeling
Description	Estrogen Receptor-α (ERα) plays a crucial role in breast cancer, driving the transcription of genes involved in tumor progression. The ERα function is dependent on multiple protein-protein interactions (PPIs). As a result of rapid tumor adaptation, these are often altered by drug treatments and acquired mutations. Although elucidating how ERα PPIs evolve in response to therapies is critical to fully uncover drug resistance, capturing transient interactions in their subcellular context remains a major challenge. In this study, we used Biotinylation by Antibody Recognition (BAR) coupled with mass spectrometry to investigate the ERα proximal proteome and its perturbations associated with endocrine resistance.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:38:41.164.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Graeme Benstead-Hume
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-06-26 02:42:22	ID requested
1	2024-05-09 02:36:35	announced
⏵ 2	2024-10-22 06:38:41	announced	2024-10-22: Updated project metadata.

Publication List

Rega C, Kozik Z, Yu L, Tsitsa I, Martin LA, Choudhary J, Exploring the Spatial Landscape of the Estrogen Receptor Proximal Proteome With Antibody-Based Proximity Labeling. Mol Cell Proteomics, 23(1):100702(2024) [pubmed]
10.1016/j.mcpro.2023.100702;

Rega C, Kozik Z, Yu L, Tsitsa I, Martin LA, Choudhary J, Exploring the Spatial Landscape of the Estrogen Receptor Proximal Proteome With Antibody-Based Proximity Labeling. Mol Cell Proteomics, 23(1):100702(2024) [pubmed]

10.1016/j.mcpro.2023.100702;

Keyword List

submitter keyword: Estrogen receptor, endocrine resistance, BAR, interactome

submitter keyword: Estrogen receptor, endocrine resistance, BAR, interactome

Contact List

Jyoti Choudhary
contact affiliation	Functional Proteomics, ICR
contact email	jyoti.choudhary@icr.ac.uk
lab head
Graeme Benstead-Hume
contact affiliation	ICR
contact email	ghume@icr.ac.uk
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD043294
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD043294

PRIDE project URI

Repository Record List

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