PXD043285

PXD043285 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of the four rat models of depression
Description	Major depressive disorder (MDD) is a highly heterogeneous psychiatric disorder. The pathogenesis of MDD remained unclear, and it may be associated with exposure to different stressors. Most previous studies have focused on molecular changes in a single stress-induced depression model, which limited the identification of the pathogenesis of MDD. The depressive-like behaviors were induced by four well-validated stress models in rats, including chronic unpredictable mild stress, learned helplessness stress, chronic restraint stress and social defeat stress. We applied proteomic to investigate molecular changes in the hippocampus of those four models and revealed 529 proteins.
HostingRepository	iProX
AnnounceDate	2023-05-22
AnnouncementXML	Submission_2024-02-22_18:19:11.815.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xuemei Li
SpeciesList	scientific name: Rattus norvegicus; NCBI TaxID: 10116;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2023-06-25 21:29:13	ID requested
⏵ 1	2024-02-22 18:19:12	announced

Li X, Teng T, Yan W, Fan L, Liu X, Clarke G, Zhu D, Jiang Y, Xiang Y, Yu Y, Zhang Y, Yin B, Lu L, Zhou X, Xie P, AKT and MAPK signaling pathways in hippocampus reveals the pathogenesis of depression in four stress-induced models. Transl Psychiatry, 13(1):200(2023) [pubmed]

submitter keyword: Proteomic, hippocampus, depression model, rat

Peng Xie
contact affiliation	The First Affiliated Hospital of Chongqing Medical University
contact email	xiepeng@cqmu.edu.cn
lab head
Xuemei Li
contact affiliation	The First Affiliated Hospital of Chongqing Medical University
contact email	xuemeililucky@126.com
dataset submitter

iProX dataset URI