PXD043265

PXD043265 is an original dataset announced via ProteomeXchange.

Title	Proteome Landscapes of Human Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma
Description	Liver cancer is among the top leading causes of cancer mortality worldwide. Particularly, hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (CCA) have been extensively investigated from the aspect of tumor biology. However, a comprehensive and systematic understanding of the molecular characteristics of HCC and CCA remains absent. Here, we characterized the proteome landscapes of HCC and CCA using the data-independent acquisition (DIA) mass spectrometry (MS) method. By comparing the quantitative proteomes of HCC and CCA, we found several differences between the two cancer types. In particular, we found an abnormal lipid metabolism in HCC and activated extracellular matrix-related pathways in CCA. We next developed a three-protein classifier to distinguish CCA from HCC, achieving an area under the curve (AUC) of 0.92, and an accuracy of 90% in an independent validation cohort of 51 patients. The distinct molecular characteristics of HCC and CCA presented in this study provide new insights into the tumor biology of these two major important primary liver cancers. Our findings may help develop more efficient diagnosis protocols and new targeted drug treatments.
HostingRepository	iProX
AnnounceDate	2023-06-21
AnnouncementXML	Submission_2023-10-26_19:12:04.672.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yi Zhu
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF; TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2023-06-24 20:42:55	ID requested
1	2023-09-19 21:05:38	announced
⏵ 2	2023-10-26 19:12:05	announced	2023-10-27: Update publication information.

Yi X, Zhu J, Liu W, Peng L, Lu C, Sun P, Huang L, Nie X, Huang S, Guo T, Zhu Y, Proteome Landscapes of Human Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma. Mol Cell Proteomics, 22(8):100604(2023) [pubmed]

submitter keyword: hepatocellular carcinoma, intrahepatic cholangiocarcinoma, proteomics

Tiannan Guo
contact affiliation	Westlake University
contact email	guotianan@westlake.edu.cn
lab head
Yi Zhu
contact affiliation	Westlake University
contact email	zhuyi@westlake.edu.cn
dataset submitter

iProX dataset URI