PXD043257

PXD043257 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	SWATH proteomics of NMN effects
Description	Nicotinamide mononucleotide (NMN) has emerged as a promising therapeutic intervention for age-related disorders, including Type 2 Diabetes. In this study, we investigated the effects of NMN treatment on glucose uptake and its underlying mechanisms in mouse tissues (muscle, liver, brain and adipose tissue) and cell lines (HepG2 and C2C12). Through a comprehensive proteomic analysis, we uncovered a series of distinct organ-specific effects that contribute to the observed improvements in glucose metabolism.
HostingRepository	PRIDE
AnnounceDate	2024-06-16
AnnouncementXML	Submission_2024-06-16_04:13:22.906.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Roua Popescu
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	TripleTOF 5600

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-06-23 21:40:21	ID requested
⏵ 1	2024-06-16 04:13:23	announced

Publication List

10.3390/ijms25052594;
Popescu RG, Dinischiotu A, Soare T, Vlase E, Marinescu GC, Nicotinamide Mononucleotide (NMN) Works in Type 2 Diabetes through Unexpected Effects in Adipose Tissue, Not by Mitochondrial Biogenesis. Int J Mol Sci, 25(5):(2024) [pubmed]

10.3390/ijms25052594;

Popescu RG, Dinischiotu A, Soare T, Vlase E, Marinescu GC, Nicotinamide Mononucleotide (NMN) Works in Type 2 Diabetes through Unexpected Effects in Adipose Tissue, Not by Mitochondrial Biogenesis. Int J Mol Sci, 25(5):(2024) [pubmed]

Keyword List

submitter keyword: DIA-NN, C2C12, mouse, SWATH-MS,NMN, HepG2

submitter keyword: DIA-NN, C2C12, mouse, SWATH-MS,NMN, HepG2

Contact List

George Catalin Marinescu
contact affiliation	Proteomics Department, Independent Research Association, Bucharest, Romania
contact email	Catalin.Marinescu@independent-research.ro
lab head
Roua Popescu
contact affiliation	Independent Research Association
contact email	roua@independent-research.ro
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/06/PXD043257
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/06/PXD043257

PRIDE project URI

Repository Record List

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