PXD043238

PXD043238 is an original dataset announced via ProteomeXchange.

Title	A SWI/SNF-dependent transcriptional repression mediated by POU2AF2/C11orf53 at enhancer.
Description	Recent studies have identified a previously uncharacterized protein C11orf53 (now named POU2AF2/OCA-T1), functions as a new co-activator of POU2F3, the master transcription factor which is critical for both normal and neoplastic tuft cell identity and viability. Here, we demonstrated that POU2AF2 functions as an “Yin-Yang” factor which mediates both transcriptional activation and repression at distal enhance elements. The proteomics study aims to identify potential interactors with POU2AF2 in different cell lines which may enable us to further understand the function of POU2AF2 in human cancer.
HostingRepository	PRIDE
AnnounceDate	2024-01-19
AnnouncementXML	Submission_2024-01-19_09:29:04.318.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lu Wang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2023-06-23 06:25:21	ID requested
⏵ 1	2024-01-19 09:29:04	announced

Dataset with its publication pending

submitter keyword: co-activator,POU2AF2, SWI/SNF, small cell lung cancer

Lu Wang
contact affiliation	Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
contact email	lu.wang1@northwestern.edu
lab head
Lu Wang
contact affiliation	Northwestern University
contact email	lu.wang1@northwestern.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/01/PXD043238

PRIDE project URI

• PRIDE
  1. PXD043238
     1. Label: PRIDE project
     2. Name: A SWI/SNF-dependent transcriptional repression mediated by POU2AF2/C11orf53 at enhancer.