PXD043224

PXD043224 is an original dataset announced via ProteomeXchange.

Title	Identification of serum biomarkers to monitor therapeutic response in gastric cancer
Description	There are a limited number of clinically useful serum biomarkers to predict tumour onset or treatment response in gastric cancer (GC). For this reason, we explored the serum proteome of the gp130Y757F murine model of intestinal-type gastric cancer (IGC). We identified 30 proteins with significantly elevated expression in early gp130Y757F IGC and 12 proteins that were significantly elevated in late gp130Y757F IGC compared to age and gender matched wild-type mice. Within these signatures, there was an overlap of 10 proteins commonly elevated in both early and late-stage disease. Since IGC in the gp130Y757F model can be reversed following therapeutic inhibition of Interleukin (IL)-11, we explored whether the protein signatures we identified could be used to monitor tumour regression. We compared two different therapeutic modalities and found 5 proteins to be uniquely differentially expressed between control and treated animals half-way through treatment, with 10 differentially expressed at the end of treatment. Our findings highlight the potential to identify reliable biomarkers to track IGC tumor regression in response to treatment.
HostingRepository	PRIDE
AnnounceDate	2024-03-19
AnnouncementXML	Submission_2024-03-19_04:52:50.777.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Laura Dagley
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	impact II

Revision	Datetime	Status	ChangeLog Entry
0	2023-06-22 22:57:13	ID requested
⏵ 1	2024-03-19 04:52:51	announced

10.3390/IJMS25063129;

submitter keyword: biomarker;Interleukin-11

intestinal-type gastric cancer

mouse model

proteomics

Associate Professor Tracy Putoczki
contact affiliation	Laboratory Head, Personalised Oncology Division Associate Professor, Department of Medical Biology, University of Melbourne, Australia
contact email	putoczki.t@wehi.edu.au
lab head
Laura Dagley
contact affiliation	WEHI
contact email	dagley.l@wehi.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/03/PXD043224

PRIDE project URI

• PRIDE
  1. PXD043224
     1. Label: PRIDE project
     2. Name: Identification of serum biomarkers to monitor therapeutic response in gastric cancer