⮝ Full datasets listing
PXD043222
PXD043222 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Conditional SPI1 deletion exacerbates amyloid pathology through modulating microglial functions in a mouse model of Abeta amyloidosis |
| Description | Recent human genetic studies have highlighted microglia genes and its regulatory mechanisms involved in the pathogenesis of Alzheimer disease (AD). The transcription factor PU.1 (encoded by SPI1) is mainly expressed in microglia in the nervous system and has been reported as a genetic risk factor for AD. However, the role of microglial SPI1 on AD etiology is still poorly understood. Here, we first demonstrated that the loss of microglial Spi1 exacerbates amyloid pathologies in an AD mouse model (APP/PS1). Specifically, microglial Spi1 deficiency increases amyloid deposition, gliosis, dystrophic neurites, while decreasing plaque-associated microglia by modulating microglial phagocytic activity. Furthermore, we identified several potential biological networks, such as immune response_phagocytosis and Neurophysiological process, which are regulated by altered microglial Spi1 through the analyses of proteomics and transcriptomics data. Our findings broaden understanding of the role of microglial SPI1 in amyloid pathology and provide a rich dataset for future analyses of SPI1 in AD. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-04-03 |
| AnnouncementXML | Submission_2026-04-03_09:55:12.877.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Kim Lab |
| SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
| ModificationList | Phospho; TMTpro; Carbamidomethyl; Met-loss+Acetyl; Deamidated; Oxidation |
| Instrument | Orbitrap Eclipse |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-06-22 19:51:51 | ID requested | |
| ⏵ 1 | 2026-04-03 09:55:15 | announced |
Publication List
| Kim B, Tate MD, Karahan H, Wijeratne HRS, Sharify AD, Wang SS, Kim JR, Al-Amin MM, Hartigan K, Chung S, Dabin LC, Acri DJ, Doud EH, John SK, Mosley AL, Kim J, Deletion of SPI1 in microglia exacerbates amyloid pathology by impairing microglial response in Alzheimer's disease models. Neuron, ():(2026) [pubmed] |
Keyword List
| submitter keyword: SPI1, PU.1, Alzheimer's disease, brain, microglia, APP/PS1 |
Contact List
| Jungsu Kim | |
|---|---|
| contact affiliation | Indiana University School of Medicine |
| contact email | jk123@iu.edu |
| lab head | |
| Kim Lab | |
| contact affiliation | IUSM |
| contact email | jk123@iu.edu |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v05/MSV000092244/ |
