PXD043206

PXD043206 is an original dataset announced via ProteomeXchange.

Title	HIV/SARS-CoV-2 co-infection mediated proteomic changes in CNS potentiate neuro-HIV
Description	Coronavirus disease 2019 (COVID-19) survivors frequently experience a wide range of symptoms known as post-acute sequelae of SARS-CoV-2 (PASC) or long COVID. Importantly, complications arising from microvascular dysfunction, blood-brain barrier (BBB) disruption, and chronic neuroinflammation have been implicated in driving PASC within the central nervous system, collectively known as neuro-PASC. Notably, people living with HIV (PWH) many of whom suffer from chronic neuroinflammation, BBB impairment, and glial cell dysfunction collectively known as neuroHIV are generally at higher risk of neuro-PASC. The overlap between neuro-PASC and neuroHIV raises concerns that HIV and SARS-CoV-2 co-infection may exacerbate neurological dysfunctions among PWH. In this study we examine the effects of HIV and SARS-CoV-2 mono- and co-infection in microglia, astrocytes and pericytes Our results demonstrated that first, both all brain cells support restrictive SARS-CoV-2 replication in presence or absence of HIV infection. Furthermore, in both mono and co-infected cells, there was a notable increase in the expression of SARS-CoV-2 host cell entry factors like ACE2, TMPRSS2, NRP1, and TRIM28 and inflammatory mediators. Moreover, conditioned media collected from astrocytes and pericytes were neurotoxic. Additionally, proteomic analysis has revealed distinct pathway regulation across infection conditions, with gene set enrichment highlighting top pathways linked to neurodegenerative disorders, including Alzheimer’s, Parkinson’s, Huntington’s disease, and amyotrophic lateral sclerosis. These findings underscore the potential chances of exacerbate neurological complications in PWH after SARS-CoV-2 infection.
HostingRepository	PRIDE
AnnounceDate	2026-09-07
AnnouncementXML	Submission_2026-09-06_16:30:38.665.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Akos Vegvari
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2023-06-22 04:50:33	ID requested
⏵ 1	2026-09-06 16:30:39	announced

10.1002/jmv.71086;

Acharya A, Thurman M, Sutar D, Olasunkanmi OI, Malik JR, Dyavar SR, V, é, gv, á, ri Á, Byrareddy SN, In-Vitro Evaluation of HIV/SARS-CoV-2 Co-Infection Mediated Proteomic Changes in Astrocytes and Pericytes Reveals Altered Signaling Pathways Associated With Neurodegenerative Disorders. J Med Virol, 98(8):e71086(2026) [pubmed]

submitter keyword: None

Akos Vegvari
contact affiliation	Karolinska Institutet
contact email	akos.vegvari@ki.se
lab head
Akos Vegvari
contact affiliation	Karolinska Institutet
contact email	akos.vegvari@ki.se
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD043206
     1. Label: PRIDE project
     2. Name: HIV/SARS-CoV-2 co-infection mediated proteomic changes in CNS potentiate neuro-HIV