PXD043196 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Widespread Involvement of Acetylation in the Retinal Metabolism of Form-Deprivation Myopia in Guinea Pigs |
Description | Myopia has become the major cause of visual impairment worldwide. Although the pathogenesis of myopia remains controversial, proteomics studies suggest that dysregulation of retinal metabolism is potentially involved in the pathology of myopia. Lysine acetylation of proteins plays a key role in regulating cellular metabolism, but little is known about its role in the form-deprived myopic retina. In this study, we performed acetylation proteomic analysis of the retinas of form-deprived myopic guinea pigs and found downregulated levels of acetylation of metabolism-critical enzymes in the retina. As the first report on retinal acetylation in myopic eyes, this study provides a reliable basis for further studies on retinal acetylation in myopic eyes |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_05:53:39.283.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | jiaojiao Feng |
SpeciesList | scientific name: Cavia porcellus (Guinea pig); NCBI TaxID: 10141; |
ModificationList | acetylated residue |
Instrument | timsTOF Pro 2 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-06-21 22:46:31 | ID requested | |
1 | 2023-07-12 01:23:42 | announced | |
2 | 2023-11-14 07:09:27 | announced | 2023-11-14: Updated project metadata. |
⏵ 3 | 2024-10-22 05:53:39 | announced | 2024-10-22: Updated project metadata. |
Publication List
Keyword List
submitter keyword: form-deprivation myopia |
retina |
lysine acetylation |
glycolysis |
Contact List
Hongsheng Bi |
contact affiliation | Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine |
contact email | hongshengbi1@163.com |
lab head | |
jiaojiao Feng |
contact affiliation | Shandong University of Traditional Chinese Medicine |
contact email | szyykxfjj2021@163.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD043196
- Label: PRIDE project
- Name: Widespread Involvement of Acetylation in the Retinal Metabolism of Form-Deprivation Myopia in Guinea Pigs