PXD043069

PXD043069 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	PRM and DDA Data for IR5 WIW and WIW Nanobodies
Description	Journal Article: Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils
HostingRepository	MassIVE
AnnounceDate	2023-11-16
AnnouncementXML	Submission_2023-11-16_12:32:19.530.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Eileen
SpeciesList	scientific name: Synthetic Antibodies; scientific name: Nanobodies;
ModificationList	unknown modification; unknown modification
Instrument	Orbitrap Exploris 480

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-06-16 22:42:51	ID requested
⏵ 1	2023-11-16 12:32:20	announced

Publication List

Abskharon R, Pan H, Sawaya MR, Seidler PM, Olivares EJ, Chen Y, Murray KA, Zhang J, Lantz C, Bentzel M, Boyer DR, Cascio D, Nguyen BA, Hou K, Cheng X, Pardon E, Williams CK, Nana AL, Vinters HV, Spina S, Grinberg LT, Seeley WW, Steyaert J, Glabe CG, Ogorzalek Loo RR, Loo JA, Eisenberg DS, Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils. Proc Natl Acad Sci U S A, 120(41):e2300258120(2023) [pubmed]

Abskharon R, Pan H, Sawaya MR, Seidler PM, Olivares EJ, Chen Y, Murray KA, Zhang J, Lantz C, Bentzel M, Boyer DR, Cascio D, Nguyen BA, Hou K, Cheng X, Pardon E, Williams CK, Nana AL, Vinters HV, Spina S, Grinberg LT, Seeley WW, Steyaert J, Glabe CG, Ogorzalek Loo RR, Loo JA, Eisenberg DS, Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils. Proc Natl Acad Sci U S A, 120(41):e2300258120(2023) [pubmed]

Keyword List

submitter keyword: Synthetic Antibodies, Amyloid, Nanobodies, Tau, Prion-like Spreading, Inhibitor, Fibril, Protein Structure, Neurodegeneration, Structural Biology, Seeding, Zipper Interface , Blood-Brain Barrier

submitter keyword: Synthetic Antibodies, Amyloid, Nanobodies, Tau, Prion-like Spreading, Inhibitor, Fibril, Protein Structure, Neurodegeneration, Structural Biology, Seeding, Zipper Interface , Blood-Brain Barrier

Contact List

Joseph A. Loo
contact affiliation	University of California, Los Angeles
contact email	jloo@chem.ucla.edu
lab head
David S. Eisenberg
contact affiliation	University of California, Los Angeles
contact email	david@mbi.ucla.edu
lab head
Rachel R. Ogorzalek Loo
contact affiliation	University of California, Los Angeles
contact email	rloo@mednet.ucla.edu
lab head
Eileen
contact affiliation	UCLA
contact email	eileenolivares@g.ucla.edu
dataset submitter

Full Dataset Link List

MassIVE dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000092197/

MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000092197/