PXD043063

PXD043063 is an original dataset announced via ProteomeXchange.

Title	Comparison of adhesion complex-associated proteins in MDA-MB-231 cells in a 2D vs 3D microenvironment
Description	Cell invasion and metastasis is a multi-step process, initiated by the acquisition of a migratory phenotype and the ability to move through differing and complex 3D extracellular environments. In this study we set out to identify the parameters required for invasive cell migration in 3D environments. Cells interact with the extracellular matrix via transmembrane-spanning integrin adhesion complexes. We establish a technique to determine the composition of cell-matrix adhesion complexes in invasive breast cancer cells in 3D matrices and on 2D surfaces and identify an interaction complex that is enriched in 3D adhesion sites and required for invasive migration.
HostingRepository	PRIDE
AnnounceDate	2024-02-07
AnnouncementXML	Submission_2024-02-07_06:47:48.014.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mark Morgan
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	biotinylated residue; phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2023-06-16 12:13:52	ID requested
⏵ 1	2024-02-07 06:47:48	announced

10.1016/J.CELREP.2023.113554;

submitter keyword: Human, breast cancer, ECM, adhesion, ARHGEF7, Talin, integrin, focal adhesion, betaPIX, extracellular matrix, Paxillin

Mark Richard Morgan
contact affiliation	Institute of Systems, MOlecular & Intergative Biology, Faculty of Health & Life Sciences, University of Liverpool
contact email	mark.morgan@liverpool.ac.uk
lab head
Mark Morgan
contact affiliation	Institute of Systems, Molecular & Integrative Biology University of Liverpool
contact email	mark.morgan@liverpool.ac.uk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD043063
     1. Label: PRIDE project
     2. Name: Comparison of adhesion complex-associated proteins in MDA-MB-231 cells in a 2D vs 3D microenvironment