PXD043035

PXD043035 is an original dataset announced via ProteomeXchange.

Title	Quantitative proteomics investigation of total protein and acetylated 4D Label free of 18 samples from H9C2 cells
Description	The quantitative investigation of acetylated proteomics was carried out in this project. To ensure high reliability of the results, we filtered the identification data using a criterion of localization probability>0.75. This study identified a total of 9755 acetylation sites located on 3051 proteins, of which the quantitative information from 6323 sites of 2005 proteins were obtained. Subsequently, we conducted a systematic bioinformatics analysis of proteins which containing quantitative information sites, including protein annotation, functional classification, functional enrichment, and cluster analysis based on functional enrichment. According to above information, we provided reference directions for downstream in-depth research based on proteomics.
HostingRepository	iProX
AnnounceDate	2023-06-16
AnnouncementXML	Submission_2025-06-13_00:00:46.263.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yisa Wang
SpeciesList	scientific name: Rattus norvegicus; NCBI TaxID: 10116;
ModificationList	acetylated residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2023-06-15 18:43:38	ID requested
1	2023-06-15 18:44:07	announced
⏵ 2	2025-06-13 00:00:47	announced	2025-06-13: Add Publication.

Huang Q, Yao Y, Wang Y, Li J, Chen J, Wu M, Guo C, Lou J, Yang W, Zhao L, Tong X, Zhao D, Li X, Ginsenoside Rb2 inhibits p300-mediated SF3A2 acetylation at lysine 10 to promote Fscn1 alternative splicing against myocardial ischemic/reperfusion injury. J Adv Res, 65():365-379(2024) [pubmed]

submitter keyword: ginsenosides, acetylated proteomics, H9C2 cells, 4D label free, oxygen-glucose deprivation, ischemia-reperfusion injury

Xiangyan Li
contact affiliation	Changchun University of Traditional Chinese Medicine
contact email	xiangyan_li1981@163.com
lab head
Yisa Wang
contact affiliation	Northeast Asia Institute of Traditional Chinese Medicine, Changchun University of Traditional Chinese Medicine
contact email	wys_isaacwong@163.com
dataset submitter

iProX dataset URI