PXD043019 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Mapping of bone marrow sample proteome of Pinch1/2 knockout mice |
Description | Mesenchymal stromal cells (MSCs) are used to treat infectious and immune diseases and disorders; however, its mechanism(s) remain incompletely defined. Here we find that MSCs lacking Pinch1/2 proteins display dramatically reduced ability to suppress lipopolysaccharide (LPS)-induced acute lung injury and dextran sulfate sodium (DSS)-induced inflammatory bowel disease in mice. Mice with Pinch loss in MSCs have severe defects in both immune and hematopoietic functions, resulting in premature death, which can be restored by intravenous injection of wild-type but not Pinch-deficient MSCs. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:16:55.780.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Tailin He |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | timsTOF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2023-06-15 06:36:09 | ID requested | |
1 | 2023-12-07 19:38:23 | announced | |
⏵ 2 | 2024-10-22 06:16:56 | announced | 2024-10-22: Updated project metadata. |
Publication List
Keyword List
submitter keyword: inflammation, complement,Focal adhesion, Pinch |
Contact List
Tailin He |
contact affiliation | Southern University of Science and Technology |
contact email | hetailin@126.com |
lab head | |
Tailin He |
contact affiliation | Southern University of Science and Technology |
contact email | hetailin@126.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/12/PXD043019 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD043019
- Label: PRIDE project
- Name: Mapping of bone marrow sample proteome of Pinch1/2 knockout mice