PXD043019

PXD043019 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Mapping of bone marrow sample proteome of Pinch1/2 knockout mice
Description	Mesenchymal stromal cells (MSCs) are used to treat infectious and immune diseases and disorders; however, its mechanism(s) remain incompletely defined. Here we find that MSCs lacking Pinch1/2 proteins display dramatically reduced ability to suppress lipopolysaccharide (LPS)-induced acute lung injury and dextran sulfate sodium (DSS)-induced inflammatory bowel disease in mice. Mice with Pinch loss in MSCs have severe defects in both immune and hematopoietic functions, resulting in premature death, which can be restored by intravenous injection of wild-type but not Pinch-deficient MSCs.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:16:55.780.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tailin He
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-06-15 06:36:09	ID requested
1	2023-12-07 19:38:23	announced
⏵ 2	2024-10-22 06:16:56	announced	2024-10-22: Updated project metadata.

Publication List

10.1038/S41418-023-01243-9;

10.1038/S41418-023-01243-9;

Keyword List

submitter keyword: inflammation, complement,Focal adhesion, Pinch

submitter keyword: inflammation, complement,Focal adhesion, Pinch

Contact List

Tailin He
contact affiliation	Southern University of Science and Technology
contact email	hetailin@126.com
lab head
Tailin He
contact affiliation	Southern University of Science and Technology
contact email	hetailin@126.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/12/PXD043019
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/12/PXD043019

PRIDE project URI

Repository Record List

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