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PXD043019

PXD043019 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMapping of bone marrow sample proteome of Pinch1/2 knockout mice
DescriptionMesenchymal stromal cells (MSCs) are used to treat infectious and immune diseases and disorders; however, its mechanism(s) remain incompletely defined. Here we find that MSCs lacking Pinch1/2 proteins display dramatically reduced ability to suppress lipopolysaccharide (LPS)-induced acute lung injury and dextran sulfate sodium (DSS)-induced inflammatory bowel disease in mice. Mice with Pinch loss in MSCs have severe defects in both immune and hematopoietic functions, resulting in premature death, which can be restored by intravenous injection of wild-type but not Pinch-deficient MSCs.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_06:16:55.780.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterTailin He
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumenttimsTOF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-06-15 06:36:09ID requested
12023-12-07 19:38:23announced
22024-10-22 06:16:56announced2024-10-22: Updated project metadata.
Publication List
10.1038/S41418-023-01243-9;
Keyword List
submitter keyword: inflammation, complement,Focal adhesion, Pinch
Contact List
Tailin He
contact affiliationSouthern University of Science and Technology
contact emailhetailin@126.com
lab head
Tailin He
contact affiliationSouthern University of Science and Technology
contact emailhetailin@126.com
dataset submitter
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Dataset FTP location
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PRIDE project URI
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