PXD042935

PXD042935 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Deubiquitination of CDC6 by OTUD6A promotes tumour progression and chemoresistance
Description	CDC6 is an oncogenic protein whose expression level fluctuates during the cell cycle. Although several E3 ubiquitin ligases responsible for the ubiquitin-mediated proteolysis of CDC6 have been identified, the deubiquitination pathway for CDC6 has not been investigated. Here, we report that OTUD6A functions as a deubiquitinase of CDC6. OTUD6A promotes cell proliferation and decreases sensitivity to chemotherapy by upregulating CDC6 protein expression.
HostingRepository	PRIDE
AnnounceDate	2024-05-24
AnnouncementXML	Submission_2024-05-24_02:49:07.328.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	xc liu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-06-13 01:08:07	ID requested
⏵ 1	2024-05-24 02:49:08	announced

Publication List

10.1186/s12943-024-01996-y;
Cui J, Liu X, Shang Q, Sun S, Chen S, Dong J, Zhu Y, Liu L, Xia Y, Wang Y, Xiang L, Fan B, Zhan J, Zhou Y, Chen P, Zhao R, Liu X, Xing N, Wu D, Shi B, Zou Y, by OTUD6A promotes tumour progression and chemoresistance. Mol Cancer, 23(1):86(2024) [pubmed]

10.1186/s12943-024-01996-y;

Cui J, Liu X, Shang Q, Sun S, Chen S, Dong J, Zhu Y, Liu L, Xia Y, Wang Y, Xiang L, Fan B, Zhan J, Zhou Y, Chen P, Zhao R, Liu X, Xing N, Wu D, Shi B, Zou Y, by OTUD6A promotes tumour progression and chemoresistance. Mol Cancer, 23(1):86(2024) [pubmed]

Keyword List

submitter keyword: OTUD6A, Deubiquitinase, HEK293

submitter keyword: OTUD6A, Deubiquitinase, HEK293

Contact List

Jianfeng Cui
contact affiliation	Department of Urology, Qilu Hospital of Shandong University, Jinan, China
contact email	cjf5945@sina.com
lab head
xc liu
contact affiliation	qilu hospital
contact email	dolphin11065@163.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD042935
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD042935

PRIDE project URI

Repository Record List

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