PXD042909

PXD042909 is an original dataset announced via ProteomeXchange.

Title	The Golgi stacking protein GRASP55 represents an effector protein of the natural compound Prodigiosin
Description	The bacterial secondary metabolite prodigiosin has been shown to exert anticancer, antimalarial, antibacterial and immunomodulatory properties. With regard to cancer, it has been reported that it affects tumor cells but not non-malignant cells, making it a promising lead compound for anticancer drug discovery. However, a direct protein target has not yet been experimentally identified. Here, we identify the Golgi stacking protein GRASP55 as effector target protein of prodigiosin and found evidence that GRASP55 knockout cells show an altered pattern on secreted proteins upon prodigionsin treatment.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:11:32.921.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Gereon Poschmann
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2023-06-12 05:22:30	ID requested
1	2023-10-24 13:15:43	announced
⏵ 2	2023-11-14 09:11:39	announced	2023-11-14: Updated project metadata.

Berning L, Lenz T, Bergmann AK, Poschmann G, Brass HUC, Schl, ü, termann D, Friedrich A, Mendiburo MJ, David C, Akg, ü, n S, Pietruszka J, St, ü, hler K, Stork B, The Golgi stacking protein GRASP55 is targeted by the natural compound prodigiosin. Cell Commun Signal, 21(1):275(2023) [pubmed]

submitter keyword: Prodigiosin

Golgi apparatus

Natural Compound

Autophagy

Target Identification

Secretome

Gereon Poschmann
contact affiliation	Proteome Research (AG Stühler) Institute of Molecular Medicine Heinrich Heine University Düsseldorf Universitätsstraße 1 40225 Düsseldorf Germany
contact email	gereon.poschmann@hhu.de
lab head
Gereon Poschmann
contact affiliation	Molecular Proteomics Laboratory
contact email	gereon.poschmann@hhu.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/10/PXD042909

PRIDE project URI

• PRIDE
  1. PXD042909
     1. Label: PRIDE project
     2. Name: The Golgi stacking protein GRASP55 represents an effector protein of the natural compound Prodigiosin