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PXD042909

PXD042909 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThe Golgi stacking protein GRASP55 represents an effector protein of the natural compound Prodigiosin
DescriptionThe bacterial secondary metabolite prodigiosin has been shown to exert anticancer, antimalarial, antibacterial and immunomodulatory properties. With regard to cancer, it has been reported that it affects tumor cells but not non-malignant cells, making it a promising lead compound for anticancer drug discovery. However, a direct protein target has not yet been experimentally identified. Here, we identify the Golgi stacking protein GRASP55 as effector target protein of prodigiosin and found evidence that GRASP55 knockout cells show an altered pattern on secreted proteins upon prodigionsin treatment.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_09:11:32.921.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterGereon Poschmann
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListacetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-06-12 05:22:30ID requested
12023-10-24 13:15:43announced
22023-11-14 09:11:39announced2023-11-14: Updated project metadata.
Publication List
Berning L, Lenz T, Bergmann AK, Poschmann G, Brass HUC, Schl, ü, termann D, Friedrich A, Mendiburo MJ, David C, Akg, ü, n S, Pietruszka J, St, ü, hler K, Stork B, The Golgi stacking protein GRASP55 is targeted by the natural compound prodigiosin. Cell Commun Signal, 21(1):275(2023) [pubmed]
Keyword List
submitter keyword: Prodigiosin
Golgi apparatus
Natural Compound
Autophagy
Target Identification
Secretome
Contact List
Gereon Poschmann
contact affiliationProteome Research (AG Stühler) Institute of Molecular Medicine Heinrich Heine University Düsseldorf Universitätsstraße 1 40225 Düsseldorf Germany
contact emailgereon.poschmann@hhu.de
lab head
Gereon Poschmann
contact affiliationMolecular Proteomics Laboratory
contact emailgereon.poschmann@hhu.de
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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