PXD042856

PXD042856 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Galectin-3 and prohibitin 1 are autoantigens in IgG4-related cholangitis without protective effects against toxic bile acids
Description	IgG4-related cholangitis (IRC) is the hepatobiliary manifestation of IgG4-related disease, a systemic B-cell-driven fibroinflammatory disorder. Four autoantigens have recently been described in IgG4-RD; annexin A11, galectin-3, laminin 511-E8, and prohibitin 1. We have previously reported a protective role of annexin A11 and laminin 511-E8 in human cholangiocytes against toxic bile acids. Here we explored a potentially protective role of the carbohydrate binding lectin galectin-3 and the scaffold proteins prohibitin 1 and 2.
HostingRepository	PRIDE
AnnounceDate	2024-01-23
AnnouncementXML	Submission_2024-01-23_12:35:29.949.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Harmjan Vos
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-06-09 08:09:53	ID requested
⏵ 1	2024-01-23 12:35:30	announced

Publication List

10.3389/FIMMU.2023.1251134;

10.3389/FIMMU.2023.1251134;

Keyword List

submitter keyword: cholangiopathy
cholestasis
IgG4-related systemic disease
immune-mediated disease
secretory organs

submitter keyword: cholangiopathy

cholestasis

IgG4-related systemic disease

immune-mediated disease

secretory organs

Contact List

Ulrich Beuers
contact affiliation	Department of Gastroenterology and Hepatology Tytgat Institute for Liver and Intestinal Research Amsterdam UMC, University of Amsterdam
contact email	u.h.beuers@amsterdamumc.nl
lab head
Harmjan Vos
contact affiliation	University Medical Center Utrecht Dept. Molecular Cancer Research
contact email	h.r.vos-3@umcutrecht.nl
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/01/PXD042856
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/01/PXD042856

PRIDE project URI

Repository Record List

[ + ]