PXD042828

PXD042828 is an original dataset announced via ProteomeXchange.

Title	mRNA decapping activators Pat1 and Dhh1 regulate transcript abundance and translation to tune cellular responses to nutrient availability
Description	We have examined the roles of yeast mRNA decapping-activators Pat1 and Dhh1 in repressing the translation and abundance of specific mRNAs in nutrient-replete cells using a combination of ribosome profiling, RNA-Seq, CAGE analysis of capped mRNAs, RNA Polymerase II ChIP-Seq, and TMT-mass spectrometry of mutants lacking one or both factors.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:11:38.271.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Anil Kumar Vijjamarri
SpeciesList	scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: 4932;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2023-06-08 11:58:14	ID requested
1	2023-10-24 13:36:33	announced
2	2023-11-14 08:48:48	announced	2023-11-14: Updated project metadata.
⏵ 3	2023-11-14 09:11:51	announced	2023-11-14: Updated project metadata.

Vijjamarri AK, Gupta N, Onu C, Niu X, Zhang F, Kumar R, Lin Z, Greenberg ML, Hinnebusch AG, mRNA decapping activators Pat1 and Dhh1 regulate transcript abundance and translation to tune cellular responses to nutrient availability. Nucleic Acids Res, 51(17):9314-9336(2023) [pubmed]

Vijjamarri AK, Niu X, Vandermeulen MD, Onu C, Zhang F, Qiu H, Gupta N, Gaikwad S, Greenberg ML, Cullen PJ, Lin Z, Hinnebusch AG, Decapping factor Dcp2 controls mRNA abundance and translation to adjust metabolism and filamentation to nutrient availability. Elife, 12():(2023) [pubmed]

submitter keyword: mRNA decay,Saccharomyces cerevisiea, yeast, translation

Alan G Hinnebusch
contact affiliation	NIH Distinguished Investigator Section on Nutrient Control of Gene Expression Building 6, Room 230 6 Center Drive Bethesda, MD 20892 Phone: 301-496-4480
contact email	alanh@mail.nih.gov
lab head
Anil Kumar Vijjamarri
contact affiliation	National Institutes of Health
contact email	anilkumar.vijjamarri@nih.gov
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/10/PXD042828

PRIDE project URI

• PRIDE
  1. PXD042828
     1. Label: PRIDE project
     2. Name: mRNA decapping activators Pat1 and Dhh1 regulate transcript abundance and translation to tune cellular responses to nutrient availability