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PXD042828

PXD042828 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitlemRNA decapping activators Pat1 and Dhh1 regulate transcript abundance and translation to tune cellular responses to nutrient availability
DescriptionWe have examined the roles of yeast mRNA decapping-activators Pat1 and Dhh1 in repressing the translation and abundance of specific mRNAs in nutrient-replete cells using a combination of ribosome profiling, RNA-Seq, CAGE analysis of capped mRNAs, RNA Polymerase II ChIP-Seq, and TMT-mass spectrometry of mutants lacking one or both factors.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_09:11:38.271.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAnil Kumar Vijjamarri
SpeciesList scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: 4932;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-06-08 11:58:14ID requested
12023-10-24 13:36:33announced
22023-11-14 08:48:48announced2023-11-14: Updated project metadata.
32023-11-14 09:11:51announced2023-11-14: Updated project metadata.
Publication List
Vijjamarri AK, Gupta N, Onu C, Niu X, Zhang F, Kumar R, Lin Z, Greenberg ML, Hinnebusch AG, mRNA decapping activators Pat1 and Dhh1 regulate transcript abundance and translation to tune cellular responses to nutrient availability. Nucleic Acids Res, 51(17):9314-9336(2023) [pubmed]
Vijjamarri AK, Niu X, Vandermeulen MD, Onu C, Zhang F, Qiu H, Gupta N, Gaikwad S, Greenberg ML, Cullen PJ, Lin Z, Hinnebusch AG, Decapping factor Dcp2 controls mRNA abundance and translation to adjust metabolism and filamentation to nutrient availability. Elife, 12():(2023) [pubmed]
Keyword List
submitter keyword: mRNA decay,Saccharomyces cerevisiea, yeast, translation
Contact List
Alan G Hinnebusch
contact affiliationNIH Distinguished Investigator Section on Nutrient Control of Gene Expression Building 6, Room 230 6 Center Drive Bethesda, MD 20892 Phone: 301-496-4480
contact emailalanh@mail.nih.gov
lab head
Anil Kumar Vijjamarri
contact affiliationNational Institutes of Health
contact emailanilkumar.vijjamarri@nih.gov
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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