PXD042821

PXD042821 is an original dataset announced via ProteomeXchange.

Title	Stepwise emergence of the neuronal gene expression program in early animal evolution
Description	The assembly of the neuronal and other major cell type programs occurred early in animal evolution. We can reconstruct this process by studying non-bilaterians like placozoans. These small disc-shaped animals have only nine morphologically described cell types and no neurons, but show coordinated behaviors triggered by peptide-secreting cells. We investigated the possible neuronal affinities of these peptidergic cells using phylogenetics, chromatin profiling, and comparative single-cell genomics in four placozoans species. We found highly conserved cell type expression programs across placozoans, including populations of transdifferentiating and cycling cells suggestive of active cell type homeostasis. We also uncovered an unexpected diversity of fourteen peptidergic cell types that express neuronal-associated components like the presynaptic scaffold and that derive from progenitor cells with neurogenesis signatures. In contrast, earlier-branching animals like sponges and ctenophores lacked this conserved expression. Our findings indicate that key neuronal developmental and effector gene modules evolved before the advent of cnidarian/bilaterian neurons in the context of paracrine cell signalling.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:13:40.538.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Eduard Sabidó
SpeciesList	scientific name: Hoilungia hongkongensis; NCBI TaxID: 1964320; scientific name: Trichoplax sp. H2; NCBI TaxID: 287889;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2023-06-08 03:16:14	ID requested
1	2023-11-10 08:51:30	announced
⏵ 2	2023-11-14 09:13:46	announced	2023-11-14: Updated project metadata.

Najle SR, Grau-Bov, é X, Elek A, Navarrete C, Cianferoni D, Chiva C, Ca, ñ, as-Armenteros D, Mallabiabarrena A, Kamm K, Sabid, ó E, Gruber-Vodicka H, Schierwater B, Serrano L, Seb, é, -Pedr, ó, s A, Stepwise emergence of the neuronal gene expression program in early animal evolution. Cell, 186(21):4676-4693.e29(2023) [pubmed]

submitter keyword: mass spectrometry, evolution,neuropeptides

Eduard Sabido
contact affiliation	Centre for Genomic Regulation
contact email	eduard.sabido@crg.cat
lab head
Eduard Sabidó
contact affiliation	Centre de Regulació Genòmica
contact email	eduard.sabido@crg.cat
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/11/PXD042821

PRIDE project URI

• PRIDE
  1. PXD042821
     1. Label: PRIDE project
     2. Name: Stepwise emergence of the neuronal gene expression program in early animal evolution