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PXD042797

PXD042797 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleVitamin C (ascorbate) modulates the levels of several proteins in the heart of mice
DescriptionIn the present study, we used the Gulo-/- female and male mice model which depends entirely on ascorbate derived from the diet. Importantly, the levels of ascorbate found in the serum of Gulo-/- mice reflect the amounts of ascorbate provided in drinking water. We tested different concentrations of ascorbate ranging from 0 to 0.4% (w/v) ascorbate, added into drinking water, until the age of four months. We performed label-free Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) global quantitative proteomic profiling to identify and quantify proteins in whole heart extracts from our different ascorbate treated cohorts of Gulo-/- females and males.
HostingRepositoryMassIVE
AnnounceDate2024-09-30
AnnouncementXMLSubmission_2024-09-30_07:41:35.712.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMichel Lebel
SpeciesList scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090;
ModificationList4-hydroxy-L-proline
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-06-07 08:18:08ID requested
12024-09-30 07:41:36announced
Publication List
no publication
Keyword List
submitter keyword: Vitamin C, ascorbate, gulonolactone oxidase, mass spectrometry, heart, mouse
Contact List
Michel Lebel
contact affiliationCentre Hospitalier Universite Laval
contact emailmichel.lebel@crchudequebec.ulaval.ca
lab head
Michel Lebel
contact affiliationCHudeQuebe
contact emailmichel.lebel@crchudequebec.ulaval.ca
dataset submitter
Full Dataset Link List
MassIVE dataset URI
Dataset FTP location
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