PXD042792
PXD042792 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Multi-omic analysis of Esophageal Adenocarcinoma uncovers candidate therapeutic targets and cancer-selective post-transcriptional regulation |
Description | Efforts to address the poor prognosis associated with esophageal adenocarcinoma (EAC) have been hampered by a lack of biomarkers to identify early disease and therapeutic targets. Despite extensive efforts to understand the somatic mutations associated with EAC over the past decade, a gap remains in understanding how the atlas of genomic aberrations in this cancer impacts the proteome and which somatic variants are of importance for the disease phenotype. We performed a quantitative proteomic analysis of 23 EACs and matched adjacent normal esophageal and gastric tissues. We explored the correlation of transcript and protein abundance using tissue-matched RNAseq and proteomic data from 7 patients and further integrated these data with a cohort of EAC RNA-seq data (n=264 patients), EAC whole-genome sequencing (n=454 patients) and external published datasets. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:54:29.468.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD042792 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Javier Alfaro |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2023-06-07 04:59:26 | ID requested | |
1 | 2024-08-10 14:40:54 | announced | |
⏵ 2 | 2024-10-22 06:54:35 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.1016/j.mcpro.2024.100764; |
O'Neill JR, Y, é, benes Mayordomo M, Mitulovi, ć G, Al Shboul S, Bedran G, Faktor J, Hernychova L, Uhrik L, G, ó, mez-Herranz M, Kocikowski M, Save V, Vojt, ě, š, ek B, Arends MJ, Hupp T, Alfaro JA, Fitzgerald RC, Edwards PAW, Grehan N, Nutzinger B, Loreno C, Redmond AM, Abbas S, Freeman A, Smyth EC, O'Donovan M, Miremadi A, Malhotra S, Tripathi M, Cheah C, Coles H, Millington C, Devonshire G, Eldridge M, Secrier M, Jammula S, Davies J, Crichton C, Carroll N, Hardwick RH, Safranek P, Hindmarsh A, Sujendran V, Hayes SJ, Ang Y, Sharrocks A, Preston SR, Bagwan I, Save V, Skipworth RJE, Hupp TR, O'Neill JR, Tucker O, Beggs A, Taniere P, Puig S, Contino G, Underwood TJ, Walker RC, Grace BL, Lagergren J, Gossage J, Davies A, Chang F, Mahadeva U, Goh V, Ciccarelli FD, Sanders G, Berrisford R, Chan D, Cheong E, Kumar B, Sreedharan L, Parsons SL, Soomro I, Kaye P, Saunders J, Lovat L, Haidry R, Scott M, Sothi S, Lishman S, Hanna GB, Peters CJ, Moorthy K, Grabowska A, Turkington R, McManus D, Coleman H, Petty RD, Bartlet F, Multi-Omic Analysis of Esophageal Adenocarcinoma Uncovers Candidate Therapeutic Targets and Cancer-Selective Posttranscriptional Regulation. Mol Cell Proteomics, 23(6):100764(2024) [pubmed] |
10.6019/PXD042792; |
Keyword List
submitter keyword: esophageal adenocarcinoma |
Contact List
Javier Alfaro | |
---|---|
contact affiliation | International Center for Cancer Vaccine Science (ICCVS), University of Gdansk, Gdansk, Poland |
contact email | javier.alfaro@proteogenomics.ca |
lab head | |
Javier Alfaro | |
contact affiliation | University of Edinbuirgh |
contact email | javier.alfaro@proteogenomics.ca |
dataset submitter |
Full Dataset Link List
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/08/PXD042792 |
PRIDE project URI |
Repository Record List
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