PXD042789

PXD042789 is an original dataset announced via ProteomeXchange.

Title	Lysosome-autophagy dysfunction contribute to TDCIPP induced Aβ1-42 production in N2a-APPswe cells.
Description	Alzheimer's disease is the most common form of dementia characterized on cognitive impairment. Autophagy-lysosome dysfunction is linked to AD pathology. Tris (1,3-dichloro-2-propyl) phosphate (TDCIPP) is a widely used organophosphorus flame retardants with the potential to induce neuronal damage. We found that TDCIPP significantly increased expression of BACE1 and of Aβ42. TMT labeled proteomic study were used to reveal profile changes of N2a-APPswe cells after exposure by TDCIPP. Proteomic and bioinformatic analysis revealed that lysosomal proteins were dysregulated after TDCIPP treatment in N2a-APPswe cells. LC3, P62, CTSD, and LAMP1 were increased, while STAT1 was decreased after TDCIPP exposure and dysregulated proteins were validated by Western blotting. Our results, for the first time revealed that TDCIPP could be one of potential environment risk factors for AD development. Autophagy dysregulation may take an important role on TDCIPP induced Aβ42 production.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:42:47.345.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD042789
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Benhong Xu
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2023-06-07 03:08:48	ID requested
1	2024-05-24 03:17:09	announced
⏵ 2	2024-10-22 06:42:48	announced	2024-10-22: Updated project metadata.

10.1016/j.heliyon.2024.e26832;

Zou C, Yang T, Huang X, Ren X, Yang C, Xu B, Liu J, 1-42 production in N2a-APPswe cells. Heliyon, 10(8):e26832(2024) [pubmed]

10.6019/PXD042789;

submitter keyword: Abeta42

STAT1

Alzheimer disease;autophagy

Benhong Xu
contact affiliation	Shenzhen Center for Disease Control and Prevention
contact email	xubenhong@szcdc.net
lab head
Benhong Xu
contact affiliation	Shenzhen Center for Disease Control and Prevention
contact email	xubenhong@szcdc.net
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD042789
     1. Label: PRIDE project
     2. Name: Lysosome-autophagy dysfunction contribute to TDCIPP induced Aβ1-42 production in N2a-APPswe cells.