PXD042780

PXD042780 is an original dataset announced via ProteomeXchange.

Title	Urinary protein changes during the short-term growth and development of rats
Description	Can the urine proteome reflect short-term changes in the growth and development of animals? Do short-term developmental effects on urinary protein need to be considered when performing urine marker studies using model animals with faster growing periods? In this study, urine samples were collected from 10 Wistar rats aged 6-8 weeks 3 and 6 days apart. The results showed that the urine proteome could sensitively reflect short-term growth and development in rats. For example, comparing the urine proteome of Day 0 and Day 6, 195 differential proteins were identified after screening (FC ≥ 1.5 or ≤ 0.67, P < 0.05), and verified by randomization, the average number of randomly generated differential proteins was 17.99. At least 90.77% of the differential proteins were not randomly generated. This finding demonstrates that the differential proteins identified in the samples collected at different time points were not randomly generated. A large number of biological processes and pathways related to growth and development were enriched, which shows that the urine proteome reflects the short-term growth and development of rats, and provides a means for in-depth and meticulous study of growth and development. Moreover, an interfering factor in animal experiments using 6- to 8-week-old rats to construct models was identified. The results of this study demonstrated that there were differences in the urinary proteome in rats aged 6-8 weeks only 3-6 days apart, which suggests that the sensitivity of urinary proteomics is high and shows the sensitive and precise response of the urinary proteome to body changes.
HostingRepository	iProX
AnnounceDate	2023-06-07
AnnouncementXML	Submission_2024-02-27_18:42:21.571.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yuqing Liu
SpeciesList	scientific name: Rattus norvegicus; NCBI TaxID: 10116;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2023-06-06 21:02:43	ID requested
1	2023-06-06 21:03:02	announced
⏵ 2	2024-02-27 18:42:22	announced	2024-02-28: Update information.

Liu Y, Yang M, Wang H, Chen Y, Gao Y, Urinary protein changes during the short-term growth and development of rats. Heliyon, 10(3):e24555(2024) [pubmed]

submitter keyword: urine, proteomics, short-term growth and development

Youhe Gao
contact affiliation	Beijing Normal University
contact email	gaoyouhe@bnu.edu.cn
lab head
Yuqing Liu
contact affiliation	Beijing Normal University
contact email	202121200018@mail.bnu.edu.cn
dataset submitter

iProX dataset URI