PXD042762

PXD042762 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomic analysis of MNT-1 cells deficient in NPC1 protein
Description	A novel MNT-1 cell line deficient in NPC1 protein was generated using CRISPR/CAS9 knock-out method. In the absence of the NPC1 protein the pigmentation status of the cells was changed and alterations in the melanogenesis process were observed. In order to characterize the role of NPC1 protein in the pigmentation process we compared the proteome of the MNT-1 WT cell line with the NPC1-KO cell line.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:04:08.171.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Cristian Munteanu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-06-06 07:28:28	ID requested
1	2023-07-24 09:51:04	announced
⏵ 2	2023-11-14 09:04:09	announced	2023-11-14: Updated project metadata.

Publication List

Rus AA, Militaru IV, Popa I, Munteanu CVA, Sima LE, Platt N, Platt FM, Petrescu Ș M, NPC1 plays a role in the trafficking of specific cargo to melanosomes. J Biol Chem, 299(8):105024(2023) [pubmed]

Rus AA, Militaru IV, Popa I, Munteanu CVA, Sima LE, Platt N, Platt FM, Petrescu Ș M, NPC1 plays a role in the trafficking of specific cargo to melanosomes. J Biol Chem, 299(8):105024(2023) [pubmed]

Keyword List

submitter keyword: melanogenesis, NPC1 protein,Proteome, MNT-1

submitter keyword: melanogenesis, NPC1 protein,Proteome, MNT-1

Contact List

Stefana M. Petrescu
contact affiliation	Dept. of Molecular Cell Biology, Institute of Biochemistry of the Romanian Academy (IBRA)
contact email	stefana.petrescu@biochim.ro
lab head
Cristian Munteanu
contact affiliation	Institute of Biochemistry of the Romanian Academy (IBRA)
contact email	cristian.v.a.munteanu@gmail.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD042762
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD042762

PRIDE project URI

Repository Record List

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