PXD042748

PXD042748 is an original dataset announced via ProteomeXchange.

Title	Identification of excavatolide B targets in RAW264.7 macrophages by chemoproteomics
Description	The fused macrocycles and multiple stereocenters of briarane-type diterpenoids pose a major challenge to total synthesis and efforts to characterize their biological activities. Harnessing a scalable source of excavatolide B (excB) from cultured corals, we developed two structurally distinct clickable excB probes that retained the anti-inflammatory biological activities of excB. Here we used these probes in a chemoproteomics strategy to the cellular target(s) of excB in mammalian cells.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_07:14:30.010.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mingzi Zhang
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2023-06-05 20:45:49	ID requested
1	2023-07-20 01:55:33	announced
⏵ 2	2023-11-14 07:14:30	announced	2023-11-14: Updated project metadata.

Dataset with its publication pending

submitter keyword: Mouse, Cell line, LC-MS/MS

Mingzi M Zhang
contact affiliation	National Health Research Institutes, Institute of Molecular and Genomic Medicine
contact email	zhangmz@nhri.edu.tw
lab head
Mingzi Zhang
contact affiliation	National Health Research Institutes, Institute of Molecular and Genomic Medicine
contact email	zhangmz@nhri.edu.tw
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD042748

PRIDE project URI

• PRIDE
  1. PXD042748
     1. Label: PRIDE project
     2. Name: Identification of excavatolide B targets in RAW264.7 macrophages by chemoproteomics