PXD042732

PXD042732 is an original dataset announced via ProteomeXchange.

Title	Next-generation proteomics of brain extracellular vesicles in schizophrenia provide new clues on the altered molecular connectome
Description	Extracellular vesicles (EVs) are tiny membranous structures capable of mediating intercellular communication. In the brain, the role(s) of EVs have been extensively studied in the context of neurological diseases, but their potential implications in the neuropathology underlying human mental disorders remain largely unexplored. Here, we investigated the potential role(s) of brain EVs in schizophrenia (SZ) by analyzing these vesicles from the three post-mortem anatomical brain regions: prefrontal cortex (PFC), hippocampus (HC) and caudate (CAU), using next-generation discovery-driven proteomics. Our results indicate that EVs from SZ-affected brains present region-specific proteins associated with abnormal GABAergic and glutamatergic transmission, as well as alterations in proteins involved in synaptic decay, abnormal brain immunity, neuronal structural imbalances and impaired cell homeostasis. Our findings also provide the first evidence that molecular exchange networks are potentially active and mediated by EVs in cognitively healthy brains. These EV-mediated networks were partially reversed and largely disrupted in brains affected by SZ.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:42:45.061.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Cristina Lorca
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2023-06-05 09:28:40	ID requested
1	2024-05-24 03:10:25	announced
⏵ 2	2024-10-22 06:42:45	announced	2024-10-22: Updated project metadata.

10.3390/biomedicines12010129;

Lorca C, Fern, á, ndez-Rhodes M, S, á, nchez Mil, á, n JA, Mulet M, Elortza F, Ramos-Miguel A, Callado LF, Meana JJ, Mur M, Batalla I, Vilella E, Serra A, Gallart-Palau X, Next-Generation Proteomics of Brain Extracellular Vesicles in Schizophrenia Provide New Clues on the Altered Molecular Connectome. Biomedicines, 12(1):(2024) [pubmed]

submitter keyword: neuroinflammation, psychiatry, molecular exchange,Extracellular vesicles, immunoglobulins, systems biology, brain antibodies, psychotic spectrum

Aida Serra Maqueda
contact affiliation	Biomedical Research Institute of Lleida Dr. Pifarré Foundation (IRBLLEIDA) - +Pec Proteomics Research Group (+PPRG) - Neuroscience Area – University Hospital Arnau de Vilanova (HUAV), 80 Av. Rovira Roure, 25198, Lleida, Spain Department of Medical Basic Sciences, University of Lleida (UdL), +Pec Proteomics Research Group (+PPRG), 25198, Lleida, Spain
contact email	aida.serra@udl.cat
lab head
Cristina Lorca
contact affiliation	IMDEA Food
contact email	cristina.lorca@imdea.org
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD042732

PRIDE project URI

• PRIDE
  1. PXD042732
     1. Label: PRIDE project
     2. Name: Next-generation proteomics of brain extracellular vesicles in schizophrenia provide new clues on the altered molecular connectome