PXD042718

PXD042718 is an original dataset announced via ProteomeXchange.

Title	Environmental Conditions Elicit a Slow but Enduring Response of Histone Post-Translational Modifications in Mozambique Tilapia
Description	Histone post-translational modifications (PTMs) are epigenetic marks that operate within the central dogma of molecular biology: upon an environmental stimulus, the histone PTMs surrounding DNA can be changed in a way that modifies gene expression, and, therefore, the abundance and composition of RNA and proteins within cells (1). Once a change is induced, histone PTMs can offer organisms resilience to their environments through processes such as developmental plasticity (2, 3). The purpose of this study was to investigate whether histone PTMs mediate developmental plasticity in Mozambique tilapia facing salinity challenges. To this aim, we exposed fish to either freshwater or hypersalinity during their early critical window of development, then continued to raise the fish in either freshwater or seawater, respectively, for 18 months. Once the fish reached adulthood, we acclimated them to either freshwater or seawater. Following salinity treatments, we quantified 343 histone PTMs in the gills of each fish. We show here that histone PTMs differ dramatically between fish exposed to distinct environmental conditions for 18 months, and that the majority of histone PTM alterations persist for at least four weeks. However, histone PTMs respond minimally to salinity acclimation during adulthood. These results challenge our prior assumptions regarding the timescale of the histone PTM response, demonstrating that it does not necessarily precede the proteomic response or acclimation. Although this finding complicates our interpretation of developmental plasticity, it signifies that histone PTMs reflect prolonged exposure to environmental conditions.
HostingRepository	PanoramaPublic
AnnounceDate	2024-12-10
AnnouncementXML	Submission_2024-12-10_15:16:25.975.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Elizabeth Mojica
SpeciesList	scientific name: Oreochromis mossambicus; NCBI TaxID: 8127;
ModificationList	Dehydrated; Cation:Na; Carboxyethyl; Carbamidomethyl; Oxidation; Phospho; ADP-Ribosyl; Acetyl; Deamidated; Gln->pyro-Glu; Dioxidation; Delta:H(4)C(2); Carbamyl; GG; Gly; Malonyl; Propionamide; Dimethyl; Methyl; HNE; Trimethyl; Delta:H(4)C(2)O(-1)S(1); Cation:Cu[I]; Cation:Fe[II]; Cation:Ca[II]; Carboxymethyl; Biotin; Formyl; Amidated
Instrument	impact II

Revision	Datetime	Status	ChangeLog Entry
0	2023-06-04 21:13:46	ID requested
⏵ 1	2024-12-10 15:16:26	announced

Mojica EA, Petcu KA, K, ü, ltz D, Environmental conditions elicit a slow but enduring response of histone post-translational modifications in Mozambique tilapia. Environ Epigenet, 10(1):dvae013(2024) [pubmed]

submitter keyword: salinity, DIA, tilapia, gill, histone, PTM

Dietmar Kültz
contact affiliation	University of California, Davis
contact email	dkueltz@ucdavis.edu
lab head
Elizabeth Mojica
contact affiliation	University of California, Davis
contact email	eajarett@ucdavis.edu
dataset submitter

Panorama Public dataset URI